| Literature DB >> 23333796 |
Monis Bilal Shamsi1, Periyasamy Govindaraj, Latika Chawla, Neena Malhotra, Neeta Singh, Suneeta Mittal, Pankaj Talwar, Kumarasamy Thangaraj, Rima Dada.
Abstract
Mitochondrial DNA (mtDNA) of oocyte is critical for its function, embryo quality and development. Analysis of complete mtDNA of 49 oocytes and 18 blastocysts from 67 females opting for IVF revealed 437 nucleotide variations. 40.29% samples had either disease associated or non-synonymous novel or pathogenic mutation in evolutionarily conserved regions. Samples with disease associated mtDNA mutations had low fertilization rate and poor embryo quality, however no difference in implantation or clinical pregnancy rate was observed. Screening mtDNA from oocyte/blastocyst is a simple, clinically reliable method for diagnostic evaluation of female infertility and may reduce risk of mtDNA disease transmission.Entities:
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Year: 2013 PMID： 23333796 DOI： 10.1016/j.mito.2013.01.002
Source DB: PubMed Journal: Mitochondrion ISSN： 1567-7249 Impact factor: 4.160