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Literature DB >> 32945868

Mitochondrial Dysfunction in Obesity and Reproduction.

Manasi Das^1,2, Consuelo Sauceda^1,2, Nicholas J G Webster^1,2,3.

Abstract

Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central role of mitochondria in energy production, heme biosynthesis, calcium buffering, steroidogenesis, and apoptosis signaling within cells, understanding the molecular mechanisms behind mitochondrial dysregulation and its potential implications in disease is critical. This review will take a journey through the past and summarize what is known about mitochondrial dysfunction in various disorders, focusing on metabolic alterations and reproductive abnormalities. Evidence is presented from studies in different human populations, and rodents with genetic manipulations of pathways known to affect mitochondrial function. Published by Oxford University Press on behalf of the Endocrine Society 2020.

Entities: Chemical

Keywords: insulin resistance; lipid accumulation; mitochondrial dynamics; mitochondrial function; mitophagy; ovarian dysfunction; oxidative stress

Mesh：

Year: 2021 PMID： 32945868 PMCID： PMC7709214 DOI： 10.1210/endocr/bqaa158

Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 5.051

157 in total

1. Aging: a theory based on free radical and radiation chemistry.

Authors: D HARMAN
Journal: J Gerontol Date: 1956-07

2. Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease.

Authors: Emma M Jenkinson; Atteeq U Rehman; Tom Walsh; Jill Clayton-Smith; Kwanghyuk Lee; Robert J Morell; Meghan C Drummond; Shaheen N Khan; Muhammad Asif Naeem; Bushra Rauf; Neil Billington; Julie M Schultz; Jill E Urquhart; Ming K Lee; Andrew Berry; Neil A Hanley; Sarju Mehta; Deirdre Cilliers; Peter E Clayton; Helen Kingston; Miriam J Smith; Thomas T Warner; Graeme C Black; Dorothy Trump; Julian R E Davis; Wasim Ahmad; Suzanne M Leal; Sheikh Riazuddin; Mary-Claire King; Thomas B Friedman; William G Newman
Journal: Am J Hum Genet Date: 2013-03-28 Impact factor: 11.025

3. Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations.

Authors: Jessica L Saben; Anna L Boudoures; Zeenat Asghar; Alysha Thompson; Andrea Drury; Wendy Zhang; Maggie Chi; Andrew Cusumano; Suzanne Scheaffer; Kelle H Moley
Journal: Cell Rep Date: 2016-06-16 Impact factor: 9.423

4. Granulosa cell and oocyte mitochondrial abnormalities in a mouse model of fragile X primary ovarian insufficiency.

Authors: Carola Conca Dioguardi; Bahar Uslu; Monique Haynes; Meltem Kurus; Mehmet Gul; De-Qiang Miao; Lucia De Santis; Maurizio Ferrari; Stefania Bellone; Alessandro Santin; Cecilia Giulivi; Gloria Hoffman; Karen Usdin; Joshua Johnson
Journal: Mol Hum Reprod Date: 2016-03-09 Impact factor: 4.025

5. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study.

Authors: B C Martin; J H Warram; A S Krolewski; R N Bergman; J S Soeldner; C R Kahn
Journal: Lancet Date: 1992-10-17 Impact factor: 79.321

Review 6. Mitochondria as regulatory forces in oocytes, preimplantation embryos and stem cells.

Authors: Jonathan Van Blerkom
Journal: Reprod Biomed Online Date: 2008-04 Impact factor: 3.828

7. Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle.

Authors: Pablo Garcia-Roves; Janice M Huss; Dong-Ho Han; Chad R Hancock; Eduardo Iglesias-Gutierrez; May Chen; John O Holloszy
Journal: Proc Natl Acad Sci U S A Date: 2007-06-04 Impact factor: 11.205

8. Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from early antral follicles of aged cows.

Authors: Miyako Sugiyama; Ryoka Kawahara-Miki; Hirosuke Kawana; Koumei Shirasuna; Takehito Kuwayama; Hisataka Iwata
Journal: J Reprod Dev Date: 2015-04-12 Impact factor: 2.214

Review 9. Role of mitochondrial dysfunction and dysregulation of Ca²⁺ homeostasis in the pathophysiology of insulin resistance and type 2 diabetes.

Authors: Chih-Hao Wang; Yau-Huei Wei
Journal: J Biomed Sci Date: 2017-09-07 Impact factor: 8.410

10. Maternal overnutrition by hypercaloric diets programs hypothalamic mitochondrial fusion and metabolic dysfunction in rat male offspring.

Authors: Robbi E Cardenas-Perez; Lizeth Fuentes-Mera; Ana Laura de la Garza; Ivan Torre-Villalvazo; Luis A Reyes-Castro; Humberto Rodriguez-Rocha; Aracely Garcia-Garcia; Juan Carlos Corona-Castillo; Armando R Tovar; Elena Zambrano; Rocio Ortiz-Lopez; Jennifer Saville; Maria Fuller; Alberto Camacho
Journal: Nutr Metab (Lond) Date: 2018-06-05 Impact factor: 4.169

9 in total

1. Obesity Affects the Proliferative Potential of Equine Endometrial Progenitor Cells and Modulates Their Molecular Phenotype Associated with Mitochondrial Metabolism.

Authors: Agnieszka Smieszek; Klaudia Marcinkowska; Ariadna Pielok; Mateusz Sikora; Lukas Valihrach; Elaine Carnevale; Krzysztof Marycz
Journal: Cells Date: 2022-04-24 Impact factor: 7.666

2. Gintonin-enriched fraction protects against sarcopenic obesity by promoting energy expenditure and attenuating skeletal muscle atrophy in high-fat diet-fed mice.

Authors: Heegu Jin; Hyun-Ji Oh; Seung-Yeol Nah; Boo-Yong Lee
Journal: J Ginseng Res Date: 2021-10-13 Impact factor: 5.735

Review 3. Mitofusins: from mitochondria to fertility.

Authors: Shanjiang Zhao; Nuo Heng; Huan Wang; Haoyu Wang; Haobo Zhang; Jianfei Gong; Zhihui Hu; Huabin Zhu
Journal: Cell Mol Life Sci Date: 2022-06-20 Impact factor: 9.207

4. Accelerated Ovarian Aging Among Type 2 Diabetes Patients and Its Association With Adverse Lipid Profile.

Authors: Yahao Wang; Yangang Wang
Journal: Front Endocrinol (Lausanne) Date: 2022-03-30 Impact factor: 5.555

5. Neospora caninum infection induced mitochondrial dysfunction in caprine endometrial epithelial cells via downregulating SIRT1.

Authors: De-Liang Tao; Shan-Shan Zhao; Jin-Ming Chen; Xi Chen; Xin Yang; Jun-Ke Song; Qun Liu; Guang-Hui Zhao
Journal: Parasit Vectors Date: 2022-08-01 Impact factor: 4.047

Mitochondrial Dysfunction in Obesity and Reproduction.

1. Aging: a theory based on free radical and radiation chemistry.

2. Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease.

3. Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations.

4. Granulosa cell and oocyte mitochondrial abnormalities in a mouse model of fragile X primary ovarian insufficiency.

5. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study.

Review 6. Mitochondria as regulatory forces in oocytes, preimplantation embryos and stem cells.

7. Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle.

8. Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from early antral follicles of aged cows.

Review 9. Role of mitochondrial dysfunction and dysregulation of Ca²⁺ homeostasis in the pathophysiology of insulin resistance and type 2 diabetes.

10. Maternal overnutrition by hypercaloric diets programs hypothalamic mitochondrial fusion and metabolic dysfunction in rat male offspring.

1. Obesity Affects the Proliferative Potential of Equine Endometrial Progenitor Cells and Modulates Their Molecular Phenotype Associated with Mitochondrial Metabolism.

2. Gintonin-enriched fraction protects against sarcopenic obesity by promoting energy expenditure and attenuating skeletal muscle atrophy in high-fat diet-fed mice.

Review 3. Mitofusins: from mitochondria to fertility.

4. Accelerated Ovarian Aging Among Type 2 Diabetes Patients and Its Association With Adverse Lipid Profile.

5. Neospora caninum infection induced mitochondrial dysfunction in caprine endometrial epithelial cells via downregulating SIRT1.

6. Guava Leaf Extract Suppresses Fructose Mediated Non-Alcoholic Fatty Liver Disease in Growing Rats.

7. A 3D analysis revealed complexe mitochondria morphologies in porcine cumulus cells.

Review 8. High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus.

Review 9. The mitochondrial profile in women with polycystic ovary syndrome: impact of exercise.

Review 6. Mitochondria as regulatory forces in oocytes, preimplantation embryos and stem cells.

Review 9. Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in the pathophysiology of insulin resistance and type 2 diabetes.

Review 3. Mitofusins: from mitochondria to fertility.

Review 8. High Folate, Perturbed One-Carbon Metabolism and Gestational Diabetes Mellitus.

Review 9. The mitochondrial profile in women with polycystic ovary syndrome: impact of exercise.

Review 9. Role of mitochondrial dysfunction and dysregulation of Ca²⁺ homeostasis in the pathophysiology of insulin resistance and type 2 diabetes.