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Literature DB >> 23328477

Epigenetic abnormalities in cancer find a "home on the range".

Abstract

Recent studies have highlighted large genomic regions prone to undergo epigenetic changes in cancers. In this issue of Cancer Cell, Bert and colleagues describe novel genomic domains with aberrant epigenetic changes involving concordant activation of neighboring genes. These domains involve aberrant CpG-island hypermethylation similar to that observed in gene silencing.

Entities: Chemical Disease Species

Year: 2013 PMID： 23328477 PMCID： PMC3586528 DOI： 10.1016/j.ccr.2012.12.018

Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743

10 in total

Review 1. A decade of exploring the cancer epigenome - biological and translational implications.

Authors: Stephen B Baylin; Peter A Jones
Journal: Nat Rev Cancer Date: 2011-09-23 Impact factor: 60.716

Review 2. Functions of DNA methylation: islands, start sites, gene bodies and beyond.

Authors: Peter A Jones
Journal: Nat Rev Genet Date: 2012-05-29 Impact factor: 53.242

3. Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity.

Authors: Marcel W Coolen; Clare Stirzaker; Jenny Z Song; Aaron L Statham; Zena Kassir; Carlos S Moreno; Andrew N Young; Vijay Varma; Terence P Speed; Mark Cowley; Paul Lacaze; Warren Kaplan; Mark D Robinson; Susan J Clark
Journal: Nat Cell Biol Date: 2010-02-21 Impact factor: 28.824

4. Sequencing newly replicated DNA reveals widespread plasticity in human replication timing.

Authors: R Scott Hansen; Sean Thomas; Richard Sandstrom; Theresa K Canfield; Robert E Thurman; Molly Weaver; Michael O Dorschner; Stanley M Gartler; John A Stamatoyannopoulos
Journal: Proc Natl Acad Sci U S A Date: 2009-12-04 Impact factor: 11.205

5. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains.

Authors: Benjamin P Berman; Daniel J Weisenberger; Joseph F Aman; Toshinori Hinoue; Zachary Ramjan; Yaping Liu; Houtan Noushmehr; Christopher P E Lange; Cornelis M van Dijk; Rob A E M Tollenaar; David Van Den Berg; Peter W Laird
Journal: Nat Genet Date: 2011-11-27 Impact factor: 38.330

Review 6. Cancer genetics and epigenetics: two sides of the same coin?

Authors: Jueng Soo You; Peter A Jones
Journal: Cancer Cell Date: 2012-07-10 Impact factor: 31.743

7. Regional activation of the cancer genome by long-range epigenetic remodeling.

Authors: Saul A Bert; Mark D Robinson; Dario Strbenac; Aaron L Statham; Jenny Z Song; Toby Hulf; Robert L Sutherland; Marcel W Coolen; Clare Stirzaker; Susan J Clark
Journal: Cancer Cell Date: 2012-12-13 Impact factor: 31.743

8. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells.

Authors: Ryan Lister; Mattia Pelizzola; Yasuyuki S Kida; R David Hawkins; Joseph R Nery; Gary Hon; Jessica Antosiewicz-Bourget; Ronan O'Malley; Rosa Castanon; Sarit Klugman; Michael Downes; Ruth Yu; Ron Stewart; Bing Ren; James A Thomson; Ronald M Evans; Joseph R Ecker
Journal: Nature Date: 2011-02-02 Impact factor: 49.962

9. Increased methylation variation in epigenetic domains across cancer types.

Authors: Kasper Daniel Hansen; Winston Timp; Héctor Corrada Bravo; Sarven Sabunciyan; Benjamin Langmead; Oliver G McDonald; Bo Wen; Hao Wu; Yun Liu; Dinh Diep; Eirikur Briem; Kun Zhang; Rafael A Irizarry; Andrew P Feinberg
Journal: Nat Genet Date: 2011-06-26 Impact factor: 38.330

10. A DNA hypermethylation module for the stem/progenitor cell signature of cancer.

Authors: Hariharan Easwaran; Sarah E Johnstone; Leander Van Neste; Joyce Ohm; Tim Mosbruger; Qiuju Wang; Martin J Aryee; Patrick Joyce; Nita Ahuja; Dan Weisenberger; Eric Collisson; Jingchun Zhu; Srinivasan Yegnasubramanian; William Matsui; Stephen B Baylin
Journal: Genome Res Date: 2012-03-05 Impact factor: 9.043

10 in total

9 in total

Epigenetic abnormalities in cancer find a "home on the range".

Review 1. A decade of exploring the cancer epigenome - biological and translational implications.

Review 2. Functions of DNA methylation: islands, start sites, gene bodies and beyond.

3. Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity.

4. Sequencing newly replicated DNA reveals widespread plasticity in human replication timing.

5. Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains.

Review 6. Cancer genetics and epigenetics: two sides of the same coin?

7. Regional activation of the cancer genome by long-range epigenetic remodeling.

8. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells.

9. Increased methylation variation in epigenetic domains across cancer types.

10. A DNA hypermethylation module for the stem/progenitor cell signature of cancer.

Review 1. The epigenetics of epithelial-mesenchymal plasticity in cancer.

2. DNA Methylation and Colorectal Cancer.

3. DNA methylome profiling identifies novel methylated genes in African American patients with colorectal neoplasia.

Review 4. The epigenetic landscape of renal cancer.

Review 5. Origins of aberrant DNA methylation in acute myeloid leukemia.

Review 6. A review of toxicity and mechanisms of individual and mixtures of heavy metals in the environment.

7. DNMT3a epigenetic program regulates the HIF-2α oxygen-sensing pathway and the cellular response to hypoxia.

Review 8. Integration of genome scale data for identifying new players in colorectal cancer.

9. Investigation of EZH2 pathways for novel epigenetic treatment strategies in oropharyngeal cancer.