Literature DB >> 25580099

DNA Methylation and Colorectal Cancer.

Hassan Ashktorab1, Hassan Brim2.   

Abstract

Colorectal cancer (CRC) is one of the major cancers in the world and second death-causing cancer in the US. CRC development involves genetic and epigenetic alterations. Changes in DNA methylation status are believed to be involved at different stages of CRC. Promoter silencing via DNA methylation and hypomethylation of oncogenes alter genes' expression, and can be used as a tool for the early detection of colonic lesions. DNA methylation use as diagnostic and prognostic marker has been described for many cancers including CRC. CpG Islands Methylator Phenotype (CIMP) is one of the underlying CRC mechanisms. This review aims to define methylation signatures in CRC. The analysis of DNA methylation profile in combination with the pathological diagnosis would be useful in predicting CRC tumors' evolution and their prognostic behavior.

Entities:  

Keywords:  DNA methylation; colon cancer

Year:  2014        PMID： 25580099      PMCID： PMC4286876          DOI： 10.1007/s11888-014-0245-2

Source DB:  PubMed          Journal:  Curr Colorectal Cancer Rep        ISSN： 1556-3790


  49 in total

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Journal:  Cancer Sci       Date:  2010-11-19       Impact factor: 6.716

2.  CpG island methylator phenotype in colorectal cancer.

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Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-20       Impact factor: 11.205

3.  Short- and long-term risk of colorectal adenoma recurrence among whites and blacks.

Authors:  Adeyinka O Laiyemo; Chyke Doubeni; Hassan Brim; Hassan Ashktorab; Robert E Schoen; Samir Gupta; Aline Charabaty; Elaine Lanza; Duane T Smoot; Elizabeth Platz; Amanda J Cross
Journal:  Gastrointest Endosc       Date:  2013-01-18       Impact factor: 9.427

4.  Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition.

Authors:  Marcia Cruz-Correa; Hengmi Cui; Francis M Giardiello; Neil R Powe; Linda Hylind; Angela Robinson; David F Hutcheon; David R Kafonek; Sheri Brandenburg; Yiqian Wu; Xiaobing He; Andrew P Feinberg
Journal:  Gastroenterology       Date:  2004-04       Impact factor: 22.682

5.  Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeutics Research Group.

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Journal:  J Clin Oncol       Date:  2012-08-20       Impact factor: 44.544

6.  Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

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Journal:  Cancer Res       Date:  1998-08-01       Impact factor: 12.701

7.  Expression of the hMLH1 gene is a possible predictor for the clinical response to 5-fluorouracil after a surgical resection in colorectal cancer.

Authors:  Takao Ide; Yoshihiko Kitajima; Kazuma Ohtaka; Mayumi Mitsuno; Yuji Nakafusa; Kohji Miyazaki
Journal:  Oncol Rep       Date:  2008-06       Impact factor: 3.906

8.  Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.

Authors:  Junko Kikuchi; Taichi Takashina; Ichiro Kinoshita; Eiki Kikuchi; Yasushi Shimizu; Jun Sakakibara-Konishi; Satoshi Oizumi; Victor E Marquez; Masaharu Nishimura; Hirotoshi Dosaka-Akita
Journal:  Lung Cancer       Date:  2012-08-25       Impact factor: 5.705

9.  GATA4 and GATA5 are potential tumor suppressors and biomarkers in colorectal cancer.

Authors:  Debby M E I Hellebrekers; Marjolein H F M Lentjes; Sandra M van den Bosch; Veerle Melotte; Kim A D Wouters; Kathleen L J Daenen; Kim M Smits; Yoshimitsu Akiyama; Yasuhito Yuasa; Silvia Sanduleanu; Carolina A J Khalid-de Bakker; Daisy Jonkers; Matty P Weijenberg; Joost Louwagie; Wim van Criekinge; Beatriz Carvalho; Gerrit A Meijer; Stephen B Baylin; James G Herman; Adriaan P de Bruïne; Manon van Engeland
Journal:  Clin Cancer Res       Date:  2009-06-09       Impact factor: 12.531

10.  Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas.

Authors:  Guro E Lind; Stine A Danielsen; Terje Ahlquist; Marianne A Merok; Kim Andresen; Rolf I Skotheim; Merete Hektoen; Torleiv O Rognum; Gunn I Meling; Geir Hoff; Michael Bretthauer; Espen Thiis-Evensen; Arild Nesbakken; Ragnhild A Lothe
Journal:  Mol Cancer       Date:  2011-07-21       Impact factor: 27.401
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  21 in total

1.  Aberrant DNA methylation of acute myeloid leukemia and colorectal cancer in a Chinese pedigree with a MLL3 germline mutation.

Authors:  Fuhua Yang; Qiang Gong; Wentao Shi; Yunding Zou; Jingmin Shi; Fengjiang Wei; Qingrong Li; Jieping Chen; Wei-Dong Li
Journal:  Tumour Biol       Date:  2016-07-12

2.  CHST7 Gene Methylation and Sex-Specific Effects on Colorectal Cancer Risk.

Authors:  Haoran Bi; Yupeng Liu; Rui Pu; Tingting Xia; Hongru Sun; Hao Huang; Lei Zhang; Yuanyuan Zhang; Ying Liu; Jing Xu; Jiesheng Rong; Yashuang Zhao
Journal:  Dig Dis Sci       Date:  2019-02-28       Impact factor: 3.199

3.  Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer.

Authors:  Winston R Becker; Stephanie A Nevins; Derek C Chen; Roxanne Chiu; Aaron M Horning; Tuhin K Guha; Rozelle Laquindanum; Meredith Mills; Hassan Chaib; Uri Ladabaum; Teri Longacre; Jeanne Shen; Edward D Esplin; Anshul Kundaje; James M Ford; Christina Curtis; Michael P Snyder; William J Greenleaf
Journal:  Nat Genet       Date:  2022-06-20       Impact factor: 41.307

4.  Transcriptome profiling and co-expression network analysis of lncRNAs and mRNAs in colorectal cancer by RNA sequencing.

Authors:  Mingjie Li; Dandan Guo; Xijun Chen; Xinxin Lu; Xiaoli Huang; Yan'an Wu
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5.  Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer.

Authors:  Ulrike Peters; Li Hsu; Richard Barfield; Jeroen R Huyghe; Mathieu Lemire; Xinyuan Dong; Yu-Ru Su; Stefanie Brezina; Daniel D Buchanan; Jane C Figueiredo; Steven Gallinger; Marios Giannakis; Andrea Gsur; Marc J Gunter; Heather Hampel; Tabitha A Harrison; John L Hopper; Thomas J Hudson; Christopher I Li; Victor Moreno; Polly A Newcomb; Rish K Pai; Paul D P Pharoah; Amanda I Phipps; Conghui Qu; Robert S Steinfelder; Wei Sun; Aung Ko Win; Syed H Zaidi; Peter T Campbell
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2022-05-04       Impact factor: 4.090

6.  Epigenetics and Colorectal Neoplasia: the Evidence for Physical Activity and Sedentary Behavior.

Authors:  Elizabeth Hibler
Journal:  Curr Colorectal Cancer Rep       Date:  2015-09-19

7.  pETM: a penalized Exponential Tilt Model for analysis of correlated high-dimensional DNA methylation data.

Authors:  Hokeun Sun; Ya Wang; Yong Chen; Yun Li; Shuang Wang
Journal:  Bioinformatics       Date:  2017-06-15       Impact factor: 6.937

Review 8.  Diagnostic Performance of DNA Hypermethylation Markers in Peripheral Blood for the Detection of Colorectal Cancer: A Meta-Analysis and Systematic Review.

Authors:  Bingsheng Li; Aihua Gan; Xiaolong Chen; Xinying Wang; Weifeng He; Xiaohui Zhang; Renxiang Huang; Shuzhu Zhou; Xiaoxiao Song; Angao Xu
Journal:  PLoS One       Date:  2016-05-09       Impact factor: 3.240

9.  Increased MACC1 levels in tissues and blood identify colon adenoma patients at high risk.

Authors:  Hassan Ashktorab; Pia Hermann; Mehdi Nouraie; Babak Shokrani; Edward Lee; Tahmineh Haidary; Hassan Brim; Ulrike Stein
Journal:  J Transl Med       Date:  2016-07-20       Impact factor: 5.531

10.  α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer.

Authors:  Eric A Hanse; Amber N Habowski; Thai Q Tran; Haiqing Li; Mari B Ishak Gabra; Ying Yang; Xazmin H Lowman; Amelia M Ooi; Shu Y Liao; Robert A Edwards; Marian L Waterman; Mei Kong
Journal:  Nat Cancer       Date:  2020-03-20
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