Literature DB >> 23313330

Pericytes from human veins for treatment of myocardial ischemia.

Rajesh G Katare1, Paolo Madeddu.   

Abstract

Stem cell therapies promise to regenerate the infarcted heart through the replacement of dead cardiac cells and stimulation of neovascularization. New research from our laboratory shows the transplantation of stem cells from human veins helps heart healing after an acute ischemic insult. Using a mouse model, we demonstrated that pericytes expanded from redundant human leg veins relocate around the vessels of the peri-infarct zone and release factors that promote reparative angiogenesis and cardiomyocyte survival and inhibit interstitial fibrosis. We plan to perform a first-in-man clinical trial with human pericytes in patients with refractory myocardial ischemia in the next 5 years.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23313330      PMCID： PMC3616362          DOI： 10.1016/j.tcm.2012.09.002

Source DB:  PubMed          Journal:  Trends Cardiovasc Med        ISSN： 1050-1738            Impact factor:   6.677


  24 in total

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Review 6.  Regenerating the Cardiovascular System Through Cell Reprogramming; Current Approaches and a Look Into the Future.

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