Literature DB >> 27837475

Pericytes in Brain Injury and Repair After Ischemic Stroke.

Wei Cai1,2, Huan Liu1, Jingyan Zhao1, Lily Y Chen1, Jun Chen1, Zhengqi Lu3, Xiaoming Hu4.   

Abstract

Pericytes are functional components of the neurovascular unit (NVU). They provide support to other NVU components and maintain normal physiological functions of the blood-brain barrier (BBB). The brain ischemia and reperfusion result in pathological alterations in pericytes. The intimate anatomical and functional interactions between pericytes and other NVU components play pivotal roles in the progression of stroke pathology. In this review, we depict the biology and functions of pericytes in the normal brain and discuss their effects in brain injury and repair after ischemia/reperfusion. Since ischemic stroke occurs mostly in elderly people, we also review age-related changes in pericytes and how these changes predispose aged brains to ischemic/reperfusion injury. Strategies targeting pericyte responses after ischemia and reperfusion may provide new therapies for ischemic stroke.

Entities:  

Keywords:  Blood-brain barrier; Ischemic stroke; Neurovascular unit; Pericyte

Mesh：

Year:  2016        PMID： 27837475      PMCID： PMC5350040          DOI： 10.1007/s12975-016-0504-4

Source DB:  PubMed          Journal:  Transl Stroke Res        ISSN： 1868-4483            Impact factor:   6.829


  117 in total

1.  PDGF receptor β signaling in pericytes following ischemic brain injury.

Authors:  Koichi Arimura; Tetsuro Ago; Masahiro Kamouchi; Kuniyuki Nakamura; Koji Ishitsuka; Junya Kuroda; Hiroshi Sugimori; Hiroaki Ooboshi; Tomio Sasaki; Takanari Kitazono
Journal:  Curr Neurovasc Res       Date:  2012-02       Impact factor: 1.990

Review 2.  The role of pericytes in blood-brain barrier function and stroke.

Authors:  Shuo Liu; Dritan Agalliu; Chuanhui Yu; Mark Fisher
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

3.  Recruitment of pericytes and astrocytes is closely related to the formation of tight junction in developing retinal vessels.

Authors:  Jeong Hun Kim; Jin Hyoung Kim; Young Suk Yu; Dong Hun Kim; Kyu-Won Kim
Journal:  J Neurosci Res       Date:  2009-02-15       Impact factor: 4.164

Review 4.  Do Vascular Pericytes Contribute to Neurovasculogenesis in the Central Nervous System as Multipotent Vascular Stem Cells?

Authors:  Takayuki Nakagomi; Akiko Nakano-Doi; Miki Kawamura; Tomohiro Matsuyama
Journal:  Stem Cells Dev       Date:  2015-06-03       Impact factor: 3.272

Review 5.  Emerging roles of pericytes in the regulation of the neurovascular unit in health and disease.

Authors:  Jeremy Hill; Slava Rom; Servio H Ramirez; Yuri Persidsky
Journal:  J Neuroimmune Pharmacol       Date:  2014-08-14       Impact factor: 4.147

6.  Rat choroidal pericytes as a target of the autonomic nervous system.

Authors:  Falk Schrödl; Andrea Trost; Clemens Strohmaier; Barbara Bogner; Christian Runge; Alexandra Kaser-Eichberger; Sebastien Couillard-Despres; Ludwig Aigner; Herbert A Reitsamer
Journal:  Cell Tissue Res       Date:  2013-12-14       Impact factor: 5.249

Review 7.  Hyperglycemia, acute ischemic stroke, and thrombolytic therapy.

Authors:  Sherif Hafez; Maha Coucha; Askiel Bruno; Susan C Fagan; Adviye Ergul
Journal:  Transl Stroke Res       Date:  2014-03-13       Impact factor: 6.829

8.  Prostaglandin I2 analog suppresses lung metastasis by recruiting pericytes in tumor angiogenesis.

Authors:  Yoshinori Minami; Takaaki Sasaki; Hiroki Bochimoto; Jun-Ichi Kawabe; Satoshi Endo; Yoshiki Hira; Tsuyoshi Watanabe; Shunsuke Okumura; Naoyuki Hasebe; Yoshinobu Ohsaki
Journal:  Int J Oncol       Date:  2014-11-28       Impact factor: 5.650

9.  Insulin inhibits amyloid beta-induced cell death in cultured human brain pericytes.

Authors:  Annemieke A M Rensink; Irene Otte-Höller; Roelie de Boer; Remko R Bosch; Hans J ten Donkelaar; Robert M W de Waal; Marcel M Verbeek; Berry Kremer
Journal:  Neurobiol Aging       Date:  2004-01       Impact factor: 4.673

10.  Activity-dependent NFATc3 nuclear accumulation in pericytes from cortical parenchymal microvessels.

Authors:  Jessica A Filosa; Mark T Nelson; Laura V Gonzalez Bosc
Journal:  Am J Physiol Cell Physiol       Date:  2007-09-19       Impact factor: 4.249
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  48 in total

1.  PDGFR-β restores blood-brain barrier functions in a mouse model of focal cerebral ischemia.

Authors:  Jie Shen; Guihua Xu; Runxiu Zhu; Jun Yuan; Yoko Ishii; Takeru Hamashima; Takako Matsushima; Seiji Yamamoto; Yusuke Takatsuru; Junichi Nabekura; Masakiyo Sasahara
Journal:  J Cereb Blood Flow Metab       Date:  2018-04-09       Impact factor: 6.200

2.  Comparison of skeletal and soft tissue pericytes identifies CXCR4+ bone forming mural cells in human tissues.

Authors:  Jiajia Xu; Dongqing Li; Ching-Yun Hsu; Ye Tian; Leititia Zhang; Yiyun Wang; Robert J Tower; Leslie Chang; Carolyn A Meyers; Yongxing Gao; Kristen Broderick; Carol Morris; Jody E Hooper; Sridhar Nimmagadda; Bruno Péault; Aaron W James
Journal:  Bone Res       Date:  2020-05-22       Impact factor: 13.567

3.  Recanalization, reperfusion, and recirculation in stroke.

Authors:  John H Zhang; Andre Obenaus; David S Liebeskind; Jiping Tang; Richard Hartman; William J Pearce
Journal:  J Cereb Blood Flow Metab       Date:  2017-09-19       Impact factor: 6.200

Review 4.  Novel Regenerative Therapies Based on Regionally Induced Multipotent Stem Cells in Post-Stroke Brains: Their Origin, Characterization, and Perspective.

Authors:  Toshinori Takagi; Shinichi Yoshimura; Rika Sakuma; Akiko Nakano-Doi; Tomohiro Matsuyama; Takayuki Nakagomi
Journal:  Transl Stroke Res       Date:  2017-07-25       Impact factor: 6.829

Review 5.  The Active Role of Pericytes During Neuroinflammation in the Adult Brain.

Authors:  Fernanda Medina-Flores; Gabriela Hurtado-Alvarado; Maria A Deli; Beatriz Gómez-González
Journal:  Cell Mol Neurobiol       Date:  2022-02-23       Impact factor: 5.046

Review 6.  Dual roles of astrocytes in plasticity and reconstruction after traumatic brain injury.

Authors:  Yunxiang Zhou; Anwen Shao; Yihan Yao; Sheng Tu; Yongchuan Deng; Jianmin Zhang
Journal:  Cell Commun Signal       Date:  2020-04-15       Impact factor: 5.712

7.  Retinal Cryo-sections, Whole-Mounts, and Hypotonic Isolated Vasculature Preparations for Immunohistochemical Visualization of Microvascular Pericytes.

Authors:  Karin Dreisig; Frank Wojciechowski Blixt; Karin Warfvinge
Journal:  J Vis Exp       Date:  2018-10-07       Impact factor: 1.355

Review 8.  Pathological Continuum From the Rise in Pulse Pressure to Impaired Neurovascular Coupling and Cognitive Decline.

Authors:  Olivia de Montgolfier; Nathalie Thorin-Trescases; Eric Thorin
Journal:  Am J Hypertens       Date:  2020-04-29       Impact factor: 2.689

Review 9.  Blood-Brain Barrier Mechanisms in Stroke and Trauma.

Authors:  Wenlu Li; Fang Cao; Hajime Takase; Ken Arai; Eng H Lo; Josephine Lok
Journal:  Handb Exp Pharmacol       Date:  2022

10.  No Sweetie Pie: Newly Uncovered Role for PAI (Plasminogen Activator Inhibitor)-1 in Inflammatory Responses to Ischemia/Reperfusion.

Authors:  William P Fay; Ronald J Korthuis
Journal:  Arterioscler Thromb Vasc Biol       Date:  2018-04       Impact factor: 10.514
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