OBJECTIVE: The aim of this study was to assess the relationship between complaints of xerostomia in patients with rheumatoid arthritis (RA) with the total output of the salivary proteins of innate and adaptive immunity. STUDY DESIGN: The salivary output and specific activity of peroxidase and specific contents of lysozyme, lactoferrin, and secretory immunoglobulin A (sIgA) were determined in xerostomic RA patients, nonxerostomic RA patients, and healthy control subjects. RESULTS: Compared with nonxerostomic RA and healthy control groups, xerostomic RA patients had significantly decreased output of saliva and protein, decreased peroxidase activity, and a significantly lower specific content of peroxidase and sIgA. Compared with the RA control group, xerostomic RA patients had significantly lower specific content of all salivary proteins examined. CONCLUSIONS: The results indicate that xerostomia in patients with RA may be a harbinger of diminished saliva production regarding quantity and quality, and may be indicative of impairment of the salivary immune system of the oral cavity in xerostomic RA patients.
OBJECTIVE: The aim of this study was to assess the relationship between complaints of xerostomia in patients with rheumatoid arthritis (RA) with the total output of the salivary proteins of innate and adaptive immunity. STUDY DESIGN: The salivary output and specific activity of peroxidase and specific contents of lysozyme, lactoferrin, and secretory immunoglobulin A (sIgA) were determined in xerostomic RApatients, nonxerostomic RA patients, and healthy control subjects. RESULTS: Compared with nonxerostomic RA and healthy control groups, xerostomic RApatients had significantly decreased output of saliva and protein, decreased peroxidase activity, and a significantly lower specific content of peroxidase and sIgA. Compared with the RA control group, xerostomic RApatients had significantly lower specific content of all salivary proteins examined. CONCLUSIONS: The results indicate that xerostomia in patients with RA may be a harbinger of diminished saliva production regarding quantity and quality, and may be indicative of impairment of the salivary immune system of the oral cavity in xerostomic RApatients.
Authors: Javier Silvestre-Rangil; Leticia Bagán; Francisco Javier Silvestre; José Vicente Bagán Journal: Clin Oral Investig Date: 2016-02-18 Impact factor: 3.573
Authors: Anna Zalewska; Anna Klimiuk; Sara Zięba; Olga Wnorowska; Małgorzata Rusak; Napoleon Waszkiewicz; Izabela Szarmach; Krzysztof Dzierżanowski; Mateusz Maciejczyk Journal: Sci Rep Date: 2021-12-13 Impact factor: 4.379
Authors: Magdalena Choromańska; Anna Klimiuk; Paula Kostecka-Sochoń; Karolina Wilczyńska; Mikołaj Kwiatkowski; Natalia Okuniewska; Napoleon Waszkiewicz; Anna Zalewska; Mateusz Maciejczyk Journal: Int J Mol Sci Date: 2017-10-20 Impact factor: 5.923
Authors: K Morawska; M Maciejczyk; S Zięba; Ł Popławski; A Kita-Popławska; J Krętowski; A Zalewska Journal: Mediators Inflamm Date: 2021-07-11 Impact factor: 4.711