Literature DB >> 23306821

Vertebral fracture assessment scans enhance targeting of investigations and treatment within a fracture risk assessment pathway.

K-P Kuet1, D Charlesworth, N F A Peel.   

Abstract

UNLABELLED: Vertebral fracture assessment (VFA) scanning is a useful tool to aid vertebral fracture identification. In this evaluation, we show that introduction of a comprehensive fracture risk assessment pathway incorporating VFA has enhanced diagnosis of vertebral fractures and improved targeting of investigations and treatment.
INTRODUCTION: Vertebral fractures are a common manifestation of osteoporosis and are associated with an increased risk of future vertebral and non-vertebral fractures. VFA is a method of imaging the thoraco-lumbar spine and a useful tool to aid vertebral fracture identification. In August 2008, a new one-stop pathway was introduced incorporating VFA and laboratory investigations at the time of bone mineral density assessment. The aims of this evaluation were to evaluate the clinical utility of VFA in identifying vertebral fractures which had not presented clinically and to evaluate the impact of this on management.
METHODS: We performed a retrospective 6-month review of the new pathway focussing on those patients undergoing VFA who were suspected to have a vertebral fracture. The outcomes of VFA, spinal X-rays and investigations were evaluated.
RESULTS: Three thousand five hundred twenty-six individuals underwent fracture risk assessment over a 6-month period, of which 1,833 underwent VFA. Previously undiagnosed vertebral fractures were found in 202 individuals (36 were in retrospect apparent on prior imaging, and 29 were new vertebral fractures in patients with pre-existing vertebral fractures). Diagnosis of a vertebral fracture led to further investigation in all individuals and altered management in 59 (29 %) individuals. A potentially modifiable underlying cause was found in 42 (21 %).
CONCLUSIONS: Introduction of a fracture risk assessment service incorporating VFA and a one-stop pathway has enhanced vertebral fracture identification and targeting of treatment and management.

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Mesh:

Year:  2013        PMID: 23306821     DOI: 10.1007/s00198-012-2255-8

Source DB:  PubMed          Journal:  Osteoporos Int        ISSN: 0937-941X            Impact factor:   4.507


  32 in total

1.  Reliability and accuracy of vertebral fracture assessment with densitometry compared to radiography in clinical practice.

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2.  Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis.

Authors:  Dennis M Black; Pierre D Delmas; Richard Eastell; Ian R Reid; Steven Boonen; Jane A Cauley; Felicia Cosman; Péter Lakatos; Ping Chung Leung; Zulema Man; Carlos Mautalen; Peter Mesenbrink; Huilin Hu; John Caminis; Karen Tong; Theresa Rosario-Jansen; Joel Krasnow; Trisha F Hue; Deborah Sellmeyer; Erik Fink Eriksen; Steven R Cummings
Journal:  N Engl J Med       Date:  2007-05-03       Impact factor: 91.245

3.  Prevalent vertebral deformities predict increased mortality and increased fracture rate in both men and women: a 10-year population-based study of 598 individuals from the Swedish cohort in the European Vertebral Osteoporosis Study.

Authors:  R Hasserius; M K Karlsson; B E Nilsson; I Redlund-Johnell; O Johnell
Journal:  Osteoporos Int       Date:  2003-01       Impact factor: 4.507

4.  Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial.

Authors:  P D Delmas; H K Genant; G G Crans; J L Stock; M Wong; E Siris; J D Adachi
Journal:  Bone       Date:  2003-10       Impact factor: 4.398

5.  FRAX and the assessment of fracture probability in men and women from the UK.

Authors:  J A Kanis; O Johnell; A Oden; H Johansson; E McCloskey
Journal:  Osteoporos Int       Date:  2008-02-22       Impact factor: 4.507

6.  Effect of raloxifene on the risk of new vertebral fracture in postmenopausal women with osteopenia or osteoporosis: a reanalysis of the Multiple Outcomes of Raloxifene Evaluation trial.

Authors:  John A Kanis; Olof Johnell; Dennis M Black; Robert W Downs; Somnath Sarkar; Thomas Fuerst; Roberta J Secrest; Imre Pavo
Journal:  Bone       Date:  2003-09       Impact factor: 4.398

7.  Algorithm-based qualitative and semiquantitative identification of prevalent vertebral fracture: agreement between different readers, imaging modalities, and diagnostic approaches.

Authors:  Lynne Ferrar; Guirong Jiang; John T Schousboe; Charles R DeBold; Richard Eastell
Journal:  J Bone Miner Res       Date:  2008-03       Impact factor: 6.741

8.  Factors associated with kyphosis progression in older women: 15 years' experience in the study of osteoporotic fractures.

Authors:  Deborah M Kado; Mei-Hua Huang; Arun S Karlamangla; Peggy Cawthon; Wendy Katzman; Teresa A Hillier; Kristine Ensrud; Steven R Cummings
Journal:  J Bone Miner Res       Date:  2013-01       Impact factor: 6.741

Review 9.  Timing of subsequent fractures after an initial fracture.

Authors:  Tineke A C M van Geel; Kirsten M B Huntjens; Joop P W van den Bergh; Geert-Jan Dinant; Piet P Geusens
Journal:  Curr Osteoporos Rep       Date:  2010-09       Impact factor: 5.096

10.  Optimizing data acquisition and analysis of morphometric X-ray absorptiometry.

Authors:  J A Rea; P Steiger; G M Blake; I Fogelman
Journal:  Osteoporos Int       Date:  1998       Impact factor: 5.071

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  7 in total

1.  Identification of vertebral fractures: a moderately severe solution?

Authors:  E V McCloskey
Journal:  Osteoporos Int       Date:  2017-04-27       Impact factor: 4.507

2.  Quantitative computed tomography discriminates between postmenopausal women with low spine bone mineral density with vertebral fractures and those with low spine bone mineral density only: the SHATTER study.

Authors:  M A Paggiosi; M Debono; J S Walsh; N F A Peel; R Eastell
Journal:  Osteoporos Int       Date:  2020-01-28       Impact factor: 4.507

Review 3.  Vertebral Fracture Identification as Part of a Comprehensive Risk Assessment in Patients with Osteoporosis.

Authors:  John T Schousboe
Journal:  Curr Osteoporos Rep       Date:  2018-10       Impact factor: 5.096

4.  Prevalence of vertebral fractures and minor vertebral deformities evaluated by DXA-assisted vertebral fracture assessment (VFA) in a population-based study of postmenopausal women: the FRODOS study.

Authors:  E Kanterewicz; E Puigoriol; J García-Barrionuevo; L del Rio; M Casellas; P Peris
Journal:  Osteoporos Int       Date:  2014-03-06       Impact factor: 4.507

5.  Accuracy of densitometric vertebral fracture assessment when performed by DXA technicians--a cross-sectional, multiobserver study.

Authors:  B Rud; A Vestergaard; L Hyldstrup
Journal:  Osteoporos Int       Date:  2015-11-10       Impact factor: 4.507

6.  Effect of implementation of guidelines on assessment and diagnosis of vertebral fractures in patients older than 50 years with a recent non-vertebral fracture.

Authors:  R Y van der Velde; S P G Bours; C E Wyers; W F Lems; P P M M Geusens; J P W van den Bergh
Journal:  Osteoporos Int       Date:  2017-07-26       Impact factor: 4.507

Review 7.  Osteoporosis in men.

Authors:  Jennifer S Walsh; Richard Eastell
Journal:  Nat Rev Endocrinol       Date:  2013-09-10       Impact factor: 43.330

  7 in total

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