| Literature DB >> 23306532 |
Patricia Regina Manzine1, Jessyka Maria de França Bram, Elisabeth Joan Barham, Francisco de Assis Carvalho do Vale, Heloisa Sobreiro Selistre-de-Araújo, Márcia Regina Cominetti, Sofia Cristina Iost Pavarini.
Abstract
Alzheimer's disease (AD) is the most common cause of dementia in people above age 65. Platelet studies with ADAM10 have shown that its expression is reduced in AD patients. The aim of this research was to compare the platelet levels of ADAM10 protein in two Brazilian elderly groups, considering the stages of the disease. The SDS-PAGE technique followed by Western blotting was used. Data were analyzed using comparison, correlation and association statistical methods. The results showed reduced platelet ADAM10 levels in AD elderly compared to non-AD subjects. The disease progression intensified this reduction. ADAM10 was the only statistically significant variable (p = 0.01) to increase the AD occurrence probability. The cutoff value of 0.4212 in the receiver operating characteristic curve captured sensitivity and specificity of 70 and 80.77%, respectively. Together with other clinical criteria, ADAM10 seems to be a relevant biomarker tool for early and accurate AD diagnosis.Entities:
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Year: 2013 PMID： 23306532 DOI： 10.1159/000345983
Source DB: PubMed Journal: Dement Geriatr Cogn Disord ISSN： 1420-8008 Impact factor: 2.959