Literature DB >> 23305153

Hunanamycin A, an antibiotic from a marine-derived Bacillus hunanensis.

Youcai Hu1, Kezhan Wang, John B MacMillan.   

Abstract

Hunanamycin A, the first natural product with a pyrido[1,2,3-de]quinoxaline-2,3-dione core, was isolated from a marine-derived Bacillus hunanensis. Hunanamycin A is related to a degradation product of riboflavin but has undergone an N-prenylation and subsequent cyclization. The structure, including stereochemistry, was determined by NMR and MS methods. Hunanamycin A exhibits a minimum inhibitory concentration (MIC) of 12.4 μM against the bacterial pathogen Salmonella enterica.

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Year:  2013        PMID： 23305153     DOI： 10.1021/ol303376c

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

1.  Discoipyrroles A-D: isolation, structure determination, and synthesis of potent migration inhibitors from Bacillus hunanensis.

Authors:  Youcai Hu; Malia B Potts; Dominic Colosimo; Mireya L Herrera-Herrera; Aaron G Legako; Muhammed Yousufuddin; Michael A White; John B MacMillan
Journal:  J Am Chem Soc       Date:  2013-08-28       Impact factor: 15.419

Review 2.  Bacterial terpenome.

Authors:  Jeffrey D Rudolf; Tyler A Alsup; Baofu Xu; Zining Li
Journal:  Nat Prod Rep       Date:  2021-05-26       Impact factor: 15.111

3.  Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus.

Authors:  Peng Fu; John B MacMillan
Journal:  Org Lett       Date:  2015-05-29       Impact factor: 6.005

Review 4.  Marine Pharmacology in 2012-2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

Authors:  Alejandro M S Mayer; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Nobuhiro Fusetani
Journal:  Mar Drugs       Date:  2017-08-29       Impact factor: 5.118

5.  Route to Benzimidazol-2-ones via Decarbonylative Ring Contraction of Quinoxalinediones: Application to the Synthesis of Flibanserin, A Drug for Treating Hypoactive Sexual Desire Disorder in Women and Marine Natural Product Hunanamycin Analogue.

Authors:  Rahul D Shingare; Akshay S Kulkarni; Revannath L Sutar; D Srinivasa Reddy
Journal:  ACS Omega       Date:  2017-08-29

6.  I2-Catalyzed Carbonylation of α-Methylene Ketones to Synthesize 1,2-Diaryl Diketones and Antiviral Quinoxalines in One Pot.

Authors:  Lingkai Kong; Jieru Meng; Wenyue Tian; Jiazheng Liu; Xueping Hu; Zhi-Hong Jiang; Wei Zhang; Yanzhong Li; Li-Ping Bai
Journal:  ACS Omega       Date:  2021-12-21

Review 7.  Recent advances in the transition-metal-free synthesis of quinoxalines.

Authors:  Biplob Borah; L Raju Chowhan
Journal:  RSC Adv       Date:  2021-11-19       Impact factor: 4.036

8.  A Convenient Way to Quinoxaline Derivatives through the Reaction of 2-(3-Oxoindolin-2-yl)-2-phenylacetonitriles with Benzene-1,2-diamines.

Authors:  Alexander V Aksenov; Nikolai A Arutiunov; Dmitrii A Aksenov; Artem V Samovolov; Igor A Kurenkov; Nicolai A Aksenov; Elena A Aleksandrova; Daria S Momotova; Michael Rubin
Journal:  Int J Mol Sci       Date:  2022-09-22       Impact factor: 6.208

9.  Diphenyl Ethers from a Marine-Derived Aspergillus sydowii.

Authors:  Ya-Nan Wang; Yan-Hua Mou; Yu Dong; Yan Wu; Bing-Yu Liu; Jian Bai; Dao-Jiang Yan; Le Zhang; Dan-Qing Feng; Yue-Hu Pei; You-Cai Hu
Journal:  Mar Drugs       Date:  2018-11-16       Impact factor: 5.118

10.  Chromomycin A2 potently inhibits glucose-stimulated insulin secretion from pancreatic β cells.

Authors:  Michael A Kalwat; In Hyun Hwang; Jocelyn Macho; Magdalena G Grzemska; Jonathan Z Yang; Kathleen McGlynn; John B MacMillan; Melanie H Cobb
Journal:  J Gen Physiol       Date:  2018-10-23       Impact factor: 4.086
  10 in total

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