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Literature DB >> 23297785

Neuroimaging and other biomarkers for Alzheimer's disease: the changing landscape of early detection.

Abstract

The goal of this review is to provide an overview of biomarkers for Alzheimer's disease (AD), with emphasis on neuroimaging and cerebrospinal fluid (CSF) biomarkers. We first review biomarker changes in patients with late-onset AD, including findings from studies using structural and functional magnetic resonance imaging (MRI), advanced MRI techniques (diffusion tensor imaging, magnetic resonance spectroscopy, perfusion), positron emission tomography with fluorodeoxyglucose, amyloid tracers, and other neurochemical tracers, and CSF protein levels. Next, we evaluate findings from these biomarkers in preclinical and prodromal stages of AD including mild cognitive impairment (MCI) and pre-MCI conditions conferring elevated risk. We then discuss related findings in patients with dominantly inherited AD. We conclude with a discussion of the current theoretical framework for the role of biomarkers in AD and emergent directions for AD biomarker research.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Biomarkers

Year: 2013 PMID： 23297785 PMCID： PMC3955298 DOI： 10.1146/annurev-clinpsy-050212-185535

Source DB: PubMed Journal: Annu Rev Clin Psychol ISSN： 1548-5943 Impact factor: 18.561

159 in total

Review 1. Clinical Core of the Alzheimer's Disease Neuroimaging Initiative: progress and plans.

Authors: Paul S Aisen; Ronald C Petersen; Michael C Donohue; Anthony Gamst; Rema Raman; Ronald G Thomas; Sarah Walter; John Q Trojanowski; Leslie M Shaw; Laurel A Beckett; Clifford R Jack; William Jagust; Arthur W Toga; Andrew J Saykin; John C Morris; Robert C Green; Michael W Weiner
Journal: Alzheimers Dement Date: 2010-05 Impact factor: 21.566

2. Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.

Authors: Cunlu Xu; Zhenhua Wang; Ming Fan; Bing Liu; Ming Song; Xiantong Zhen; Tianzi Jiang
Journal: Neuroreport Date: 2010-08-23 Impact factor: 1.837

3. Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.

Authors: Heather A Wishart; Andrew J Saykin; Laura A Rabin; Robert B Santulli; Laura A Flashman; Stephen J Guerin; Alexander C Mamourian; Dorothy R Belloni; C Harker Rhodes; Thomas W McAllister
Journal: Am J Psychiatry Date: 2006-09 Impact factor: 18.112

Review 4. A meta-analysis of hippocampal atrophy rates in Alzheimer's disease.

Authors: Josephine Barnes; Jonathan W Bartlett; Laura A van de Pol; Clement T Loy; Rachael I Scahill; Chris Frost; Paul Thompson; Nick C Fox
Journal: Neurobiol Aging Date: 2008-03-17 Impact factor: 4.673

5. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis.

Authors: Kim A Celone; Vince D Calhoun; Bradford C Dickerson; Alireza Atri; Elizabeth F Chua; Saul L Miller; Kristina DePeau; Doreen M Rentz; Dennis J Selkoe; Deborah Blacker; Marilyn S Albert; Reisa A Sperling
Journal: J Neurosci Date: 2006-10-04 Impact factor: 6.167

6. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI.

Authors: A J Saykin; H A Wishart; L A Rabin; R B Santulli; L A Flashman; J D West; T L McHugh; A C Mamourian
Journal: Neurology Date: 2006-09-12 Impact factor: 9.910

7. Genome-wide association reveals genetic effects on human Aβ42 and τ protein levels in cerebrospinal fluids: a case control study.

Authors: Mi-Ryung Han; Gerard D Schellenberg; Li-San Wang
Journal: BMC Neurol Date: 2010-10-08 Impact factor: 2.474

8. Amyloid deposition is associated with impaired default network function in older persons without dementia.

Authors: Reisa A Sperling; Peter S Laviolette; Kelly O'Keefe; Jacqueline O'Brien; Dorene M Rentz; Maija Pihlajamaki; Gad Marshall; Bradley T Hyman; Dennis J Selkoe; Trey Hedden; Randy L Buckner; J Alex Becker; Keith A Johnson
Journal: Neuron Date: 2009-07-30 Impact factor: 17.173

9. Abnormal connectivity in the posterior cingulate and hippocampus in early Alzheimer's disease and mild cognitive impairment.

Authors: Yongxia Zhou; John H Dougherty; Karl F Hubner; Bing Bai; Rex L Cannon; R Kent Hutson
Journal: Alzheimers Dement Date: 2008-07 Impact factor: 21.566

10. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

Authors: Adam C Naj; Gyungah Jun; Gary W Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph D Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew J Huentelman; Amanda J Myers; Michael M Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Peter St George-Hyslop; Steven E Arnold; Robert Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; Dennis W Dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas R Galasko; Mary Ganguli; Marla Gearing; Daniel H Geschwind; Bernardino Ghetti; John R Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence S Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan I Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua W Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael A Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric M Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison M Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret A Pericak-Vance; Lindsay A Farrer; Gerard D Schellenberg
Journal: Nat Genet Date: 2011-04-03 Impact factor: 38.330

53 in total

1. Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum.

Authors: Ying Liu; Lan Tan; Hui-Fu Wang; Yong Liu; Xiao-Ke Hao; Chen-Chen Tan; Teng Jiang; Bing Liu; Dao-Qiang Zhang; Jin-Tai Yu
Journal: Mol Neurobiol Date: 2015-08-23 Impact factor: 5.590

2. Cognitive and functional patterns of nondemented subjects with equivocal visual amyloid PET findings.

Authors: P Payoux; J Delrieu; A Gallini; D Adel; A S Salabert; A Hitzel; C Cantet; M Tafani; D De Verbizier; J Darcourt; Ph Fernandez; J Monteil; I Carrié; T Voisin; S Gillette-Guyonnet; M Pontecorvo; B Vellas; S Andrieu
Journal: Eur J Nucl Med Mol Imaging Date: 2015-05-08 Impact factor: 9.236

3. Application of fused lasso logistic regression to the study of corpus callosum thickness in early Alzheimer's disease.

Authors: Sang H Lee; Donghyeon Yu; Alvin H Bachman; Johan Lim; Babak A Ardekani
Journal: J Neurosci Methods Date: 2013-10-09 Impact factor: 2.390

4. Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals.

Authors: Xiaolong Zhang; Jin-Tai Yu; Jin Li; Chao Wang; Lan Tan; Bing Liu; Tianzi Jiang
Journal: Neuropsychopharmacology Date: 2015-01-29 Impact factor: 7.853