Literature DB >> 20613678

Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.

Cunlu Xu1, Zhenhua Wang, Ming Fan, Bing Liu, Ming Song, Xiantong Zhen, Tianzi Jiang.   

Abstract

Earlier studies showed that the Val66Met polymorphisms of the brain-derived neurotrophic factor differentially affect gray matter volume and brain region activities. This study used resting positron emission tomography to investigate the relationship between the polymorphisms of Val66Met and the regional cerebral metabolic rate in the brain. We analyzed the positron emission tomography images of 215 patients from the Alzheimer's Disease Neuroimaging Initiative and found significant differences in the parahippocampal gyrus, superior temporal gyrus, prefrontal cortex, and inferior parietal lobule when comparing Met carriers with noncarriers among both the normal controls and those with mild cognitive impairment. For those with Alzheimer's disease, we also found additional differences in the bilateral insula between the carriers and noncarriers.

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Year:  2010        PMID： 20613678      PMCID： PMC2954459          DOI： 10.1097/WNR.0b013e32833ccaf4

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


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