Literature DB >> 23263685

A genomic approach to the cryptic secondary metabolome of the anaerobic world.

Anne-Catrin Letzel1, Sacha J Pidot, Christian Hertweck.   

Abstract

A total of 211 complete and published genomes from anaerobic bacteria are analysed for the presence of secondary metabolite biosynthesis gene clusters, in particular those tentatively coding for polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). We investigate the distribution of these gene clusters according to bacterial phylogeny and, if known, correlate these to the type of metabolic pathways they encode. The potential of anaerobes as secondary metabolite producers is highlighted.

Mesh：

Substances：

Year:  2012        PMID： 23263685     DOI： 10.1039/c2np20103h

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  29 in total

Review 1.  Bioinformatics tools for genome mining of polyketide and non-ribosomal peptides.

Authors:  Christopher N Boddy
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-31       Impact factor: 3.346

2.  Biosynthesis: bioinformatics bolster a renaissance.

Authors:  Ségolène Caboche
Journal:  Nat Chem Biol       Date:  2014-10       Impact factor: 15.040

Review 3.  Using natural products for drug discovery: the impact of the genomics era.

Authors:  Mingzi M Zhang; Yuan Qiao; Ee Lui Ang; Huimin Zhao
Journal:  Expert Opin Drug Discov       Date:  2017-03-14       Impact factor: 6.098

4.  Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides.

Authors:  Lin Du; April L Risinger; Carter A Mitchell; Jianlan You; Blake W Stamps; Ning Pan; Jarrod B King; Jean C Bopassa; Susan I V Judge; Zhibo Yang; Bradley S Stevenson; Robert H Cichewicz
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-10       Impact factor: 11.205

Review 5.  Methanobactin and the Link between Copper and Bacterial Methane Oxidation.

Authors:  Alan A DiSpirito; Jeremy D Semrau; J Colin Murrell; Warren H Gallagher; Christopher Dennison; Stéphane Vuilleumier
Journal:  Microbiol Mol Biol Rev       Date:  2016-03-16       Impact factor: 11.056

Review 6.  The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery.

Authors:  Paul R Jensen; Bradley S Moore; William Fenical
Journal:  Nat Prod Rep       Date:  2015-05       Impact factor: 13.423

7.  Assessing in silico the recruitment and functional spectrum of bacterial enzymes from secondary metabolism.

Authors:  Valery Veprinskiy; Leonhard Heizinger; Maximilian G Plach; Rainer Merkl
Journal:  BMC Evol Biol       Date:  2017-01-26       Impact factor: 3.260

Review 8.  Natural products from anaerobes.

Authors:  Jeffrey S Li; Colin Charles Barber; Wenjun Zhang
Journal:  J Ind Microbiol Biotechnol       Date:  2018-10-03       Impact factor: 3.346

9.  Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters.

Authors:  Peter Cimermancic; Marnix H Medema; Jan Claesen; Kenji Kurita; Laura C Wieland Brown; Konstantinos Mavrommatis; Amrita Pati; Paul A Godfrey; Michael Koehrsen; Jon Clardy; Bruce W Birren; Eriko Takano; Andrej Sali; Roger G Linington; Michael A Fischbach
Journal:  Cell       Date:  2014-07-17       Impact factor: 41.582

Review 10.  Discovery of microbial natural products by activation of silent biosynthetic gene clusters.

Authors:  Peter J Rutledge; Gregory L Challis
Journal:  Nat Rev Microbiol       Date:  2015-06-29       Impact factor: 60.633
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.