| Literature DB >> 23256747 |
Caroline E Paul1, Serena Gargiulo, Diederik J Opperman, Iván Lavandera, Vicente Gotor-Fernández, Vicente Gotor, Andreas Taglieber, Isabel W C E Arends, Frank Hollmann.
Abstract
A series of synthetic nicotinamide cofactors were synthesized to replace natural nicotinamide cofactors and promote enoate reductase (ER) catalyzed reactions without compromising the activity or stereoselectivity of the bioreduction process. Conversions and enantioselectivities of >99% were obtained for C═C bioreductions, and the process was successfully upscaled. Furthermore, high chemoselectivity was observed when employing these nicotinamide cofactor mimics (mNADs) with crude extracts in ER-catalyzed reactions.Entities:
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Year: 2012 PMID： 23256747 DOI： 10.1021/ol303240a
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005