Literature DB >> 23239898

The emerging role of the mitochondrial-derived peptide humanin in stress resistance.

Kelvin Yen1, Changhan Lee, Hemal Mehta, Pinchas Cohen.   

Abstract

The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro and also improves cardiovascular disease as well as Alzheimer's disease in vivo. In this review, we discuss the emerging role of humanin in stress resistance and its proposed mechanism of action.

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Year:  2013        PMID： 23239898      PMCID： PMC3705736          DOI： 10.1530/JME-12-0203

Source DB:  PubMed          Journal:  J Mol Endocrinol        ISSN： 0952-5041            Impact factor:   5.098


  51 in total

1.  Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes.

Authors:  Shingo Kariya; Nobuyuki Takahashi; Makito Hirano; Satoshi Ueno
Journal:  Mol Cell Biochem       Date:  2003-12       Impact factor: 3.396

2.  Humanin rescues cortical neurons from prion-peptide-induced apoptosis.

Authors:  Isabelle Sponne; Alexandre Fifre; Violette Koziel; Badreddine Kriem; Thierry Oster; Thierry Pillot
Journal:  Mol Cell Neurosci       Date:  2004-01       Impact factor: 4.314

3.  Interaction of the spectrin-like repeats of alpha-actinin-4 with humanin peptide.

Authors:  Akihiro Kigawa; Hideki Wakui; Nobuki Maki; Shin Okuyama; Rie Masai; Hiroshi Ohtani; Atsushi Komatsuda; Daisuke Suzuki; Masao Toyoda; Ryoji Kobayashi; Ken-Ichi Sawada
Journal:  Clin Exp Nephrol       Date:  2004-12       Impact factor: 2.801

4.  Sequence and organization of the human mitochondrial genome.

Authors:  S Anderson; A T Bankier; B G Barrell; M H de Bruijn; A R Coulson; J Drouin; I C Eperon; D P Nierlich; B A Roe; F Sanger; P H Schreier; A J Smith; R Staden; I G Young
Journal:  Nature       Date:  1981-04-09       Impact factor: 49.962

5.  Effect of humanin analogues on experimentally induced impairment of spatial memory in rats.

Authors:  Gabriela Krejcova; Jiri Patocka; Jirina Slaninova
Journal:  J Pept Sci       Date:  2004-10       Impact factor: 1.905

6.  Detection, localization, and sequence analyses of mitochondrial regulatory region RNAs in several mammalian species.

Authors:  N Nakamichi; D D Rhoads; J I Hayashi; Y Kagawa; T Matsumura
Journal:  J Biochem       Date:  1998-03       Impact factor: 3.387

7.  Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.

Authors:  Maaria Ikonen; Bingrong Liu; Yuichi Hashimoto; Liqun Ma; Kuk-Wha Lee; Takako Niikura; Ikuo Nishimoto; Pinchas Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-15       Impact factor: 11.205

8.  Humanin peptides block calcium influx of rat hippocampal neurons by altering fibrogenesis of Abeta(1-40).

Authors:  Ping Zou; Yanan Ding; Yinlin Sha; Baihe Hu; Songqing Nie
Journal:  Peptides       Date:  2003-05       Impact factor: 3.750

9.  N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.

Authors:  Masataka Harada; Yugo Habata; Masaki Hosoya; Kazunori Nishi; Ryo Fujii; Makoto Kobayashi; Shuji Hinuma
Journal:  Biochem Biophys Res Commun       Date:  2004-11-05       Impact factor: 3.575

10.  Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.

Authors:  Guoguang Ying; Pablo Iribarren; Ye Zhou; Wanghua Gong; Ning Zhang; Zu-Xi Yu; Yingying Le; Youhong Cui; Ji Ming Wang
Journal:  J Immunol       Date:  2004-06-01       Impact factor: 5.422
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  79 in total

1.  The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs.

Authors:  Yue Jia; Aikoui Ohanyan; Yan-He Lue; Ronald S Swerdloff; Peter Y Liu; Pinchas Cohen; Christina Wang
Journal:  Apoptosis       Date:  2015-04       Impact factor: 4.677

2.  The Mitochondria-Derived Peptide Humanin Improves Recovery from Intracerebral Hemorrhage: Implication of Mitochondria Transfer and Microglia Phenotype Change.

Authors:  Joo Eun Jung; Guanghua Sun; Jesus Bautista Garrido; Lidiya Obertas; Alexis S Mobley; Shun-Ming Ting; Xiurong Zhao; Jaroslaw Aronowski
Journal:  J Neurosci       Date:  2020-01-24       Impact factor: 6.167

Review 3.  Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.

Authors:  Bhupendra Singh; Josephine S Modica-Napolitano; Keshav K Singh
Journal:  Semin Cancer Biol       Date:  2017-05-11       Impact factor: 15.707

Review 4.  Dietary restriction, mitochondrial function and aging: from yeast to humans.

Authors:  Andrea Ruetenik; Antoni Barrientos
Journal:  Biochim Biophys Acta       Date:  2015-05-12

5.  New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects.

Authors:  Pinchas Cohen
Journal:  J Natl Cancer Inst       Date:  2014-03-01       Impact factor: 13.506

Review 6.  Numtogenesis as a mechanism for development of cancer.

Authors:  Keshav K Singh; Aaheli Roy Choudhury; Hemant K Tiwari
Journal:  Semin Cancer Biol       Date:  2017-05-13       Impact factor: 15.707

7.  The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.

Authors:  YanHe Lue; Ronald Swerdloff; Junxiang Wan; Jialin Xiao; Samuel French; Vince Atienza; Victor Canela; Kevin W Bruhn; Brian Stone; Yue Jia; Pinchas Cohen; Christina Wang
Journal:  Endocrinology       Date:  2015-09-18       Impact factor: 4.736

8.  Systemic stress signalling: understanding the cell non-autonomous control of proteostasis.

Authors:  Rebecca C Taylor; Kristen M Berendzen; Andrew Dillin
Journal:  Nat Rev Mol Cell Biol       Date:  2014-03       Impact factor: 94.444

Review 9.  Mitochondrial-epigenetic crosstalk in environmental toxicology.

Authors:  Caren Weinhouse
Journal:  Toxicology       Date:  2017-09-05       Impact factor: 4.221

Review 10.  Protective effects of Humanin and calmodulin-like skin protein in Alzheimer's disease and broad range of abnormalities.

Authors:  Masaaki Matsuoka
Journal:  Mol Neurobiol       Date:  2014-06-27       Impact factor: 5.590
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