Literature DB >> 23238671

A public-private partnership to unlock the untargeted kinome.

Stefan Knapp1, Paulo Arruda, Julian Blagg, Stephen Burley, David H Drewry, Aled Edwards, Doriano Fabbro, Paul Gillespie, Nathanael S Gray, Bernhard Kuster, Karen E Lackey, Paulo Mazzafera, Nicholas C O Tomkinson, Timothy M Willson, Paul Workman, William J Zuercher.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23238671     DOI： 10.1038/nchembio.1113

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


× No keyword cloud information.
  24 in total

1.  Comprehensive analysis of kinase inhibitor selectivity.

Authors:  Mindy I Davis; Jeremy P Hunt; Sanna Herrgard; Pietro Ciceri; Lisa M Wodicka; Gabriel Pallares; Michael Hocker; Daniel K Treiber; Patrick P Zarrinkar
Journal:  Nat Biotechnol       Date:  2011-10-30       Impact factor: 54.908

2.  The case for open-access chemical biology. A strategy for pre-competitive medicinal chemistry to promote drug discovery.

Authors:  Johan Weigelt
Journal:  EMBO Rep       Date:  2009-09       Impact factor: 8.807

3.  The art of the chemical probe.

Authors:  Stephen V Frye
Journal:  Nat Chem Biol       Date:  2010-03       Impact factor: 15.040

4.  In situ kinase profiling reveals functionally relevant properties of native kinases.

Authors:  Matthew P Patricelli; Tyzoon K Nomanbhoy; Jiangyue Wu; Heidi Brown; David Zhou; Jianming Zhang; Subadhra Jagannathan; Arwin Aban; Eric Okerberg; Chris Herring; Brian Nordin; Helge Weissig; Qingkai Yang; Jiing-Dwan Lee; Nathanael S Gray; John W Kozarich
Journal:  Chem Biol       Date:  2011-06-24

5.  Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.

Authors:  Xingyu Lin; Xi-Ping Huang; Gang Chen; Ryan Whaley; Shiming Peng; Yanli Wang; Guoliang Zhang; Simon X Wang; Shaohui Wang; Bryan L Roth; Niu Huang
Journal:  J Med Chem       Date:  2012-06-19       Impact factor: 7.446

6.  MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel.

Authors:  Toshiyasu Shimomura; Shinichi Hasako; Yoko Nakatsuru; Takashi Mita; Koji Ichikawa; Tsutomu Kodera; Takumi Sakai; Tadahiro Nambu; Mayu Miyamoto; Ikuko Takahashi; Satomi Miki; Nobuhiko Kawanishi; Mitsuru Ohkubo; Hidehito Kotani; Yoshikazu Iwasawa
Journal:  Mol Cancer Ther       Date:  2010-01-06       Impact factor: 6.261

7.  Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).

Authors:  Bryan T Mott; Cordelle Tanega; Min Shen; David J Maloney; Paul Shinn; William Leister; Juan J Marugan; James Inglese; Christopher P Austin; Tom Misteli; Douglas S Auld; Craig J Thomas
Journal:  Bioorg Med Chem Lett       Date:  2009-10-03       Impact factor: 2.823

8.  Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion.

Authors:  Sarah E Golding; Elizabeth Rosenberg; Nicholas Valerie; Isa Hussaini; Mark Frigerio; Xiaoling F Cockcroft; Wei Yee Chong; Marc Hummersone; Laurent Rigoreau; Keith A Menear; Mark J O'Connor; Lawrence F Povirk; Timothy van Meter; Kristoffer Valerie
Journal:  Mol Cancer Ther       Date:  2009-10-06       Impact factor: 6.261

9.  Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing.

Authors:  Oleg Fedorov; Kilian Huber; Andreas Eisenreich; Panagis Filippakopoulos; Oliver King; Alex N Bullock; Damian Szklarczyk; Lars J Jensen; Doriano Fabbro; Jörg Trappe; Ursula Rauch; Franz Bracher; Stefan Knapp
Journal:  Chem Biol       Date:  2011-01-28

10.  Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.

Authors:  Jianming Zhang; Francisco J Adrián; Wolfgang Jahnke; Sandra W Cowan-Jacob; Allen G Li; Roxana E Iacob; Taebo Sim; John Powers; Christine Dierks; Fangxian Sun; Gui-Rong Guo; Qiang Ding; Barun Okram; Yongmun Choi; Amy Wojciechowski; Xianming Deng; Guoxun Liu; Gabriele Fendrich; André Strauss; Navratna Vajpai; Stephan Grzesiek; Tove Tuntland; Yi Liu; Badry Bursulaya; Mohammad Azam; Paul W Manley; John R Engen; George Q Daley; Markus Warmuth; Nathanael S Gray
Journal:  Nature       Date:  2010-01-13       Impact factor: 49.962
View more
  53 in total

1.  Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity.

Authors:  Fleur M Ferguson; Zainab M Doctor; Scott B Ficarro; Christopher M Browne; Jarrod A Marto; Jared L Johnson; Tomer M Yaron; Lewis C Cantley; Nam Doo Kim; Taebo Sim; Matthew J Berberich; Marian Kalocsay; Peter K Sorger; Nathanael S Gray
Journal:  Cell Chem Biol       Date:  2019-03-28       Impact factor: 8.116

Review 2.  Ten things you should know about protein kinases: IUPHAR Review 14.

Authors:  Doriano Fabbro; Sandra W Cowan-Jacob; Henrik Moebitz
Journal:  Br J Pharmacol       Date:  2015-03-24       Impact factor: 8.739

3.  Probing questions.

Authors: 
Journal:  Nat Chem Biol       Date:  2015-08       Impact factor: 15.040

4.  SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).

Authors:  Christopher R M Asquith; Benedict-Tilman Berger; Jing Wan; James M Bennett; Stephen J Capuzzi; Daniel J Crona; David H Drewry; Michael P East; Jonathan M Elkins; Oleg Fedorov; Paulo H Godoi; Debra M Hunter; Stefan Knapp; Susanne Müller; Chad D Torrice; Carrow I Wells; H Shelton Earp; Timothy M Willson; William J Zuercher
Journal:  J Med Chem       Date:  2019-02-26       Impact factor: 7.446

5.  Stay on target.

Authors: 
Journal:  Nat Chem Biol       Date:  2013-04       Impact factor: 15.040

6.  Chemical interrogation of the malaria kinome.

Authors:  Emily R Derbyshire; Vanessa Zuzarte-Luís; Andreia D Magalhães; Nobutaka Kato; Paul C Sanschagrin; Jinhua Wang; Wenjun Zhou; Chandrasekhar V Miduturu; Ralph Mazitschek; Piotr Sliz; Maria M Mota; Nathanael S Gray; Jon Clardy
Journal:  Chembiochem       Date:  2014-08-08       Impact factor: 3.164

7.  The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner.

Authors:  Fiona P Bailey; Dominic P Byrne; Krishnadev Oruganty; Claire E Eyers; Christopher J Novotny; Kevan M Shokat; Natarajan Kannan; Patrick A Eyers
Journal:  Biochem J       Date:  2015-04-01       Impact factor: 3.857

8.  Playing well with others! Initiating and sustaining successful collaborations between industry, academia and government.

Authors:  Craig J Thomas; John C McKew
Journal:  Curr Top Med Chem       Date:  2014       Impact factor: 3.295

9.  Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets.

Authors:  Prson Gautam; Alok Jaiswal; Tero Aittokallio; Hassan Al-Ali; Krister Wennerberg
Journal:  Cell Chem Biol       Date:  2019-05-02       Impact factor: 8.116

10.  A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation.

Authors:  Alfredo Picado; Apirat Chaikuad; Carrow I Wells; Safal Shrestha; William J Zuercher; Julie E Pickett; Frank E Kwarcinski; Parvathi Sinha; Chandi S de Silva; Reena Zutshi; Shubin Liu; Natarajan Kannan; Stefan Knapp; David H Drewry; Timothy M Willson
Journal:  J Med Chem       Date:  2020-11-20       Impact factor: 7.446
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.