Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Rapid formal hydrolysis of peptide-αthioesters.

Literature DB >> 23233036

Rapid formal hydrolysis of peptide-αthioesters.

Zachary P Gates¹, Jules R Stephan, Dong Jun Lee, Stephen B H Kent.

Abstract

In the presence of 2-mercaptoethanol peptide-(α)thioesters undergo smooth conversion to their corresponding peptide-(α)carboxylates. This general and operationally simple reaction extends the utility of a promising new strategy for cleaving resin-bound Boc/benzyl-protected peptides without the use of hydrogen fluoride.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2013 PMID： 23233036 DOI： 10.1039/c2cc38229f

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

Keyword Cloud
Cited

9 in total

Review 1. Chemoenzymatic Semisynthesis of Proteins.

Authors: Robert E Thompson; Tom W Muir
Journal: Chem Rev Date: 2019-11-27 Impact factor: 60.622

2. Inteins as traceless purification tags for unnatural amino acid proteins.

Authors: Solongo Batjargal; Christopher R Walters; E James Petersson
Journal: J Am Chem Soc Date: 2015-01-27 Impact factor: 15.419

3. Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles.

Authors: Andrew G Cheetham; Yu-Chuan Ou; Pengcheng Zhang; Honggang Cui
Journal: Chem Commun (Camb) Date: 2014-04-28 Impact factor: 6.222

4. Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System.

Authors: Yusuke Tsuda; Akira Shigenaga; Kohei Tsuji; Masaya Denda; Kohei Sato; Keisuke Kitakaze; Takahiro Nakamura; Tsubasa Inokuma; Kohji Itoh; Akira Otaka
Journal: ChemistryOpen Date: 2015-04-28 Impact factor: 2.911

Rapid formal hydrolysis of peptide-αthioesters.

Review 1. Chemoenzymatic Semisynthesis of Proteins.

2. Inteins as traceless purification tags for unnatural amino acid proteins.

3. Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles.

4. Development of a Chemical Methodology for the Preparation of Peptide Thioesters Applicable to Naturally Occurring Peptides Using a Sequential Quadruple Acyl Transfer System.

5. Total chemical synthesis of SUMO-2-Lys63-linked diubiquitin hybrid chains assisted by removable solubilizing tags.

6. Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes.

7. High-affinity free ubiquitin sensors for quantifying ubiquitin homeostasis and deubiquitination.

8. HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization.

9. An explorative study towards the chemical synthesis of the immunoglobulin G1 Fc CH3 domain.