| Literature DB >> 23205935 |
Qingbo Zhang1, Huixian Li, Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Wenjun Zhang, Rong Shi, Changsheng Zhang.
Abstract
The P450 enzyme XiaM was identified as a candidate to form the C-24 carboxyl group in xiamycin A (1). Alteration of medium composition led to the discovery of four new compounds from the ΔxiaM and the ΔxiaK (encoding an aromatic ring hydroxylase) mutants. Biotransformation experiments revealed that XiaM was capable of converting a methyl group to a carboxyl group through diol and aldehyde intermediates.Entities:
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Year: 2012 PMID： 23205935 DOI： 10.1021/ol302782u
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005