Literature DB >> 23205182

A genome-wide association study of variations in maternal cardiometabolic genes and risk of placental abruption.

Amy Moore1, Daniel A Enquobahrie, Sixto E Sanchez, Cande V Ananth, Percy N Pacora, Michelle A Williams.   

Abstract

Accumulating evidence suggests that placental abruption has a complex multifactorial pathogenesis that involves cardiovascular risk and metabolic dysfunction. However, comprehensive assessment of variations in genes involved in cardiometabolic traits associated with the risk of placental abruption is lacking. We conducted a case-control study investigating associations of variations in maternal cardiometabolic genes (characterized using 217,697 SNPs on the Illumina Cardio-Metabo Chip) with risk of placental abruption. A total of 253 abruption cases and 258 controls were selected from among participants enrolled in the Peruvian Abruptio Placentae Epidemiology Study in Lima, Peru. In the genome-wide association analyses, top hits did not surpass genome-wide significance. However, we observed suggestive associations of placental abruption with several SNPs, including SNPs in SMAD2 (P-value=1.88e-6), MIR17HG (P-value=7.8e-6], and DGKB (P-value=8.35e-6] loci. In candidate gene analyses, we observed associations of variations in a priori selected genes involved in coagulation, rennin-angiotensin, angiogenesis, inflammation, and B-vitamin metabolism with the risk of abruption. Our study suggests that variations in maternal cardiovascular and metabolic genes may be associated with risk of placental abruption. Future studies with large sample sizes are warranted.

Entities:  

Keywords:  Cardio-Metabo chip; Placental abruption; genetic association; genome-wide association study; pregnancy complications; single nucleotide polymorphism

Year:  2012        PMID： 23205182      PMCID： PMC3508543     

Source DB:  PubMed          Journal:  Int J Mol Epidemiol Genet        ISSN： 1948-1756


  45 in total

1.  A common mutation in the 5,10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy.

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3.  Placental abruption is more frequent in women with the angiotensinogen Thr235 mutation.

Authors:  X Q Zhang; C Craven; L Nelson; M W Varner; K J Ward
Journal:  Placenta       Date:  2006-11-20       Impact factor: 3.481

4.  Placental abruption in the United States, 1979 through 2001: temporal trends and potential determinants.

Authors:  Cande V Ananth; Yinka Oyelese; Lami Yeo; Archana Pradhan; Anthony M Vintzileos
Journal:  Am J Obstet Gynecol       Date:  2005-01       Impact factor: 8.661

Review 5.  Thrombomodulin and its role in inflammation.

Authors:  Edward M Conway
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7.  Association of polymorphisms/haplotypes of the genes encoding vascular endothelial growth factor and its KDR receptor with recurrent pregnancy loss.

Authors:  Mei-Tsz Su; Sheng-Hsiang Lin; I-Wen Lee; Yi-Chi Chen; Pao-Lin Kuo
Journal:  Hum Reprod       Date:  2011-01-20       Impact factor: 6.918

8.  Quality control and quality assurance in genotypic data for genome-wide association studies.

Authors:  Cathy C Laurie; Kimberly F Doheny; Daniel B Mirel; Elizabeth W Pugh; Laura J Bierut; Tushar Bhangale; Frederick Boehm; Neil E Caporaso; Marilyn C Cornelis; Howard J Edenberg; Stacy B Gabriel; Emily L Harris; Frank B Hu; Kevin B Jacobs; Peter Kraft; Maria Teresa Landi; Thomas Lumley; Teri A Manolio; Caitlin McHugh; Ian Painter; Justin Paschall; John P Rice; Kenneth M Rice; Xiuwen Zheng; Bruce S Weir
Journal:  Genet Epidemiol       Date:  2010-09       Impact factor: 2.135

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Authors:  Morgan R Peltier; Cande V Ananth; Yinka Oyelese; Anthony M Vintzileos
Journal:  Epidemiology       Date:  2009-09       Impact factor: 4.822

10.  Placental thrombomodulin expression in recurrent miscarriage.

Authors:  Piergiorgio Stortoni; Monia Cecati; Stefano R Giannubilo; Davide Sartini; Angelo Turi; Monica Emanuelli; Andrea L Tranquilli
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  6 in total

1.  Genome-wide and candidate gene association studies of placental abruption.

Authors:  Tsegaselassie Workalemahu; Daniel A Enquobahrie; Amy Moore; Sixto E Sanchez; Cande V Ananth; Percy N Pacora; Liming Liang; Manuel Salazar; Michelle A Williams
Journal:  Int J Mol Epidemiol Genet       Date:  2013-09-12

2.  Genetic variations and risk of placental abruption: A genome-wide association study and meta-analysis of genome-wide association studies.

Authors:  Tsegaselassie Workalemahu; Daniel A Enquobahrie; Bizu Gelaye; Sixto E Sanchez; Pedro J Garcia; Fasil Tekola-Ayele; Anjum Hajat; Timothy A Thornton; Cande V Ananth; Michelle A Williams
Journal:  Placenta       Date:  2018-04-16       Impact factor: 3.481

3.  Circadian clock-related genetic risk scores and risk of placental abruption.

Authors:  Chunfang Qiu; Bizu Gelaye; Marie Denis; Mahlet G Tadesse; Miguel Angel Luque Fernandez; Daniel A Enquobahrie; Cande V Ananth; Sixto E Sanchez; Michelle A Williams
Journal:  Placenta       Date:  2015-10-23       Impact factor: 3.481

4.  Genetic variations related to maternal whole blood mitochondrial DNA copy number: a genome-wide and candidate gene study.

Authors:  Tsegaselassie Workalemahu; Daniel A Enquobahrie; Mahlet G Tadesse; Karin Hevner; Bizu Gelaye; Sixto E Sanchez; Michelle A Williams
Journal:  J Matern Fetal Neonatal Med       Date:  2017-04-04

5.  A donor thrombomodulin gene variation predicts graft-versus-host disease development and mortality after bone marrow transplantation.

Authors:  Haruka Nomoto; Akiyoshi Takami; J Luis Espinoza; Keitaro Matsuo; Shohei Mizuno; Makoto Onizuka; Koichi Kashiwase; Yasuo Morishima; Takahiro Fukuda; Yoshihisa Kodera; Noriko Doki; Koichi Miyamura; Takehiko Mori; Shinji Nakao; Shigeki Ohtake; Eriko Morishita
Journal:  Int J Hematol       Date:  2015-08-06       Impact factor: 2.490

6.  Placental genome and maternal-placental genetic interactions: a genome-wide and candidate gene association study of placental abruption.

Authors:  Marie Denis; Daniel A Enquobahrie; Mahlet G Tadesse; Bizu Gelaye; Sixto E Sanchez; Manuel Salazar; Cande V Ananth; Michelle A Williams
Journal:  PLoS One       Date:  2014-12-30       Impact factor: 3.240
  6 in total

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