BACKGROUND: We explored the incidence of thromboembolic disease in relatives of women diagnosed with placental abruption, a condition that may be related to disordered coagulation. METHODS: Using data from a multicenter, case-control study of placental abruption, we assessed thromboembolic diseases in first-degree male and female relatives of women with and without abruption. The analysis was restricted to biologic parents and full siblings, below 65 years of age, and corrected for familial clustering. RESULTS: The prevalence of thromboembolic disease was 7.5% in 852 relatives of 212 placental abruption cases and 4.8% in 792 relatives of 206 controls. This increased risk was driven by an association among sisters of abruption probands (odds ratio = 6.8 [95% confidence interval = 1.8-26.0]), and to a lesser extent, among mothers (2.0 [1.0-4.2]). The risk of thromboembolic diseases was similar among the male relatives of placental abruption cases and controls. CONCLUSIONS: These data suggest that thromboembolic diseases aggregate within female relatives of women with placental abruption.
BACKGROUND: We explored the incidence of thromboembolic disease in relatives of women diagnosed with placental abruption, a condition that may be related to disordered coagulation. METHODS: Using data from a multicenter, case-control study of placental abruption, we assessed thromboembolic diseases in first-degree male and female relatives of women with and without abruption. The analysis was restricted to biologic parents and full siblings, below 65 years of age, and corrected for familial clustering. RESULTS: The prevalence of thromboembolic disease was 7.5% in 852 relatives of 212 placental abruption cases and 4.8% in 792 relatives of 206 controls. This increased risk was driven by an association among sisters of abruption probands (odds ratio = 6.8 [95% confidence interval = 1.8-26.0]), and to a lesser extent, among mothers (2.0 [1.0-4.2]). The risk of thromboembolic diseases was similar among the male relatives of placental abruption cases and controls. CONCLUSIONS: These data suggest that thromboembolic diseases aggregate within female relatives of women with placental abruption.
Authors: Catalin S Buhimschi; Frederik Schatz; Graciela Krikun; Irina A Buhimschi; Charles J Lockwood Journal: Expert Rev Mol Med Date: 2010-11-01 Impact factor: 5.600
Authors: Cande V Ananth; Marianthi-Anna Kioumourtzoglou; Yongmei Huang; Zev Ross; Alexander M Friedman; Michelle A Williams; Shuang Wang; Murray A Mittleman; Joel Schwartz Journal: Epidemiology Date: 2018-09 Impact factor: 4.822
Authors: Amy Moore; Daniel A Enquobahrie; Sixto E Sanchez; Cande V Ananth; Percy N Pacora; Michelle A Williams Journal: Int J Mol Epidemiol Genet Date: 2012-11-15
Authors: Cande V Ananth; Kathleen Jablonski; Leslie Myatt; James M Roberts; Alan T N Tita; Kenneth J Leveno; Uma M Reddy; Michael W Varner; John M Thorp; Brian M Mercer; Alan M Peaceman; Susan M Ramin; Marshall W Carpenter; Philip Samuels; Anthony Sciscione; Jorge E Tolosa; George Saade; Yoram Sorokin Journal: Am J Perinatol Date: 2018-10-03 Impact factor: 1.862