Literature DB >> 23196055

Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development.

Qing Ruan1, Lei Xi, Sanford L Boye, Song Han, Zhi J Chen, William W Hauswirth, Alfed S Lewin, Michael E Boulton, Brian K Law, Wen G Jiang, Huabei Jiang, Jun Cai.   

Abstract

We aimed to develop an anti-angiogenic model for breast cancer by combining (1) siRNA-based therapy delivered by self-complementary adeno-associated virus serotype 2 (scAAV2) vectors to target tumor vasculature, and (2) noninvasive monitoring to tumor response to anti-angiogenesis by photoacoustic (PA) imaging. scAAV2 vector containing 7 surface exposed tyrosine to phenylanine capsid mutations was able to transduce microvascular endothelial cells with high efficiency. siRNAs against UPR (unfolded protein response)-IRE1α, XBP-1, ATF6 significantly inhibited breast cancer-induced angiogenesis in vitro by inhibiting endothelial cell survival. PA imaging showed that knockdown of UPR proteins greatly reduced tumor angiogenesis in vivo in breast cancer models.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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Year:  2012        PMID： 23196055      PMCID： PMC4094357          DOI： 10.1016/j.canlet.2012.11.016

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  47 in total

1.  Stable suppression of gene expression by RNAi in mammalian cells.

Authors:  Patrick J Paddison; Amy A Caudy; Gregory J Hannon
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-29       Impact factor: 11.205

2.  Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors.

Authors:  Sergei Zolotukhin; Mark Potter; Irene Zolotukhin; Yoshihisa Sakai; Scott Loiler; Thomas J Fraites; Vince A Chiodo; Tina Phillipsberg; Nicholas Muzyczka; William W Hauswirth; Terance R Flotte; Barry J Byrne; Richard O Snyder
Journal:  Methods       Date:  2002-10       Impact factor: 3.608

3.  Induction of an interferon response by RNAi vectors in mammalian cells.

Authors:  Alan J Bridge; Stephanie Pebernard; Annick Ducraux; Anne-Laure Nicoulaz; Richard Iggo
Journal:  Nat Genet       Date:  2003-07       Impact factor: 38.330

4.  Design and evaluation of a hybrid photoacoustic tomography and diffuse optical tomography system for breast cancer detection.

Authors:  Lei Xi; Xiaoqi Li; Lei Yao; Stephen Grobmyer; Huabei Jiang
Journal:  Med Phys       Date:  2012-05       Impact factor: 4.071

5.  IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.

Authors:  Marcella Calfon; Huiqing Zeng; Fumihiko Urano; Jeffery H Till; Stevan R Hubbard; Heather P Harding; Scott G Clark; David Ron
Journal:  Nature       Date:  2002-01-03       Impact factor: 49.962

6.  Adeno-associated virus vector transduction of vascular smooth muscle cells in vivo.

Authors:  M Richter; A Iwata; J Nyhuis; Y Nitta; A D Miller; C L Halbert; M D Allen
Journal:  Physiol Genomics       Date:  2000-04-27       Impact factor: 3.107

7.  XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.

Authors:  H Yoshida; T Matsui; A Yamamoto; T Okada; K Mori
Journal:  Cell       Date:  2001-12-28       Impact factor: 41.582

8.  Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice.

Authors:  Hunter C Champion; Trinity J Bivalacqua; Stanley S Greenberg; Thomas D Giles; Albert L Hyman; Philip J Kadowitz
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-17       Impact factor: 11.205

9.  Stable suppression of tumorigenicity by virus-mediated RNA interference.

Authors:  Thijn R Brummelkamp; René Bernards; Reuven Agami
Journal:  Cancer Cell       Date:  2002-09       Impact factor: 31.743

10.  Measuring changes in human tumour vasculature in response to therapy using functional imaging techniques.

Authors:  H Anderson; P Price; M Blomley; M O Leach; P Workman
Journal:  Br J Cancer       Date:  2001-10-19       Impact factor: 7.640
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  12 in total

Review 1.  The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding.

Authors:  Sarah X Zhang; Jacey H Ma; Maulasri Bhatta; Steven J Fliesler; Joshua J Wang
Journal:  Prog Retin Eye Res       Date:  2014-12-18       Impact factor: 21.198

Review 2.  Adeno-associated virus-mediated cancer gene therapy: current status.

Authors:  Jingfeng Luo; Yuxuan Luo; Jihong Sun; Yurong Zhou; Yajing Zhang; Xiaoming Yang
Journal:  Cancer Lett       Date:  2014-11-10       Impact factor: 8.679

Review 3.  Current and Emerging Clinical Applications of Multispectral Optoacoustic Tomography (MSOT) in Oncology.

Authors:  Lacey R McNally; Megan Mezera; Desiree E Morgan; Peter J Frederick; Eddy S Yang; Isam-Eldin Eltoum; William E Grizzle
Journal:  Clin Cancer Res       Date:  2016-05-20       Impact factor: 12.531

Review 4.  Adeno-associated virus (AAV) vectors in cancer gene therapy.

Authors:  Jorge L Santiago-Ortiz; David V Schaffer
Journal:  J Control Release       Date:  2016-01-12       Impact factor: 9.776

Review 5.  Advanced optoacoustic methods for multiscale imaging of in vivo dynamics.

Authors:  X L Deán-Ben; S Gottschalk; B Mc Larney; S Shoham; D Razansky
Journal:  Chem Soc Rev       Date:  2017-04-18       Impact factor: 54.564

6.  MicroRNA-214 Is Upregulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis.

Authors:  Quanlu Duan; Lei Yang; Wei Gong; Sandip Chaugai; Feng Wang; Chen Chen; Peihua Wang; Ming-Hui Zou; Dao Wen Wang
Journal:  J Cell Physiol       Date:  2015-08       Impact factor: 6.384

Review 7.  The Unfolded Protein Response in Breast Cancer.

Authors:  Eoghan P McGrath; Susan E Logue; Katarzyna Mnich; Shane Deegan; Richard Jäger; Adrienne M Gorman; Afshin Samali
Journal:  Cancers (Basel)       Date:  2018-09-21       Impact factor: 6.639

8.  IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment.

Authors:  Jonathan M Harnoss; Adrien Le Thomas; Mike Reichelt; Ofer Guttman; Thomas D Wu; Scot A Marsters; Anna Shemorry; David A Lawrence; David Kan; Ehud Segal; Mark Merchant; Klara Totpal; Lisa M Crocker; Kathryn Mesh; Monika Dohse; Margaret Solon; Zora Modrusan; Joachim Rudolph; Hartmut Koeppen; Peter Walter; Avi Ashkenazi
Journal:  Cancer Res       Date:  2020-04-07       Impact factor: 12.701

9.  Deregulation of XBP1 expression contributes to myocardial vascular endothelial growth factor-A expression and angiogenesis during cardiac hypertrophy in vivo.

Authors:  Quanlu Duan; Li Ni; Peihua Wang; Chen Chen; Lei Yang; Ben Ma; Wei Gong; Zhejun Cai; Ming-Hui Zou; Dao Wen Wang
Journal:  Aging Cell       Date:  2016-05-01       Impact factor: 9.304

10.  Spatial heterogeneity of oxygenation and haemodynamics in breast cancer resolved in vivo by conical multispectral optoacoustic mesoscopy.

Authors:  Jiao Li; Andrei Chekkoury; Jaya Prakash; Sarah Glasl; Paul Vetschera; Benno Koberstein-Schwarz; Ivan Olefir; Vipul Gujrati; Murad Omar; Vasilis Ntziachristos
Journal:  Light Sci Appl       Date:  2020-04-13       Impact factor: 17.782
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