| Literature DB >> 23195791 |
Fotini Betsou1, Elaine Gunter, Judith Clements, Yvonne DeSouza, Katrina A B Goddard, Fiorella Guadagni, Wusheng Yan, Amy Skubitz, Stella Somiari, Trina Yeadon, Rodrigo Chuaqui.
Abstract
Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is lacking, however, regarding optimal sample quality-control (QC) tools (ie, markers and assays). The aim of this review was to identify QC tools, both for fluid and solid-tissue samples, based on a comprehensive and critical literature review. The most readily applicable tools are those with a known threshold for the preanalytical variation and a known reference range for the QC analyte. Only a few meaningful markers were identified that meet these criteria, such as CD40L for assessing serum exposure at high temperatures and VEGF for assessing serum freeze-thawing. To fully assess biospecimen quality, multiple QC markers are needed. Here we present the most promising biospecimen QC tools that were identified.Entities:
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Year: 2012 PMID： 23195791 PMCID： PMC5707193 DOI： 10.1016/j.jmoldx.2012.06.008
Source DB: PubMed Journal: J Mol Diagn ISSN： 1525-1578 Impact factor: 5.568