Literature DB >> 27793884

Discovery of Anticancer Agents of Diverse Natural Origin.

A Douglas Kinghorn1,2, Esperanza J Carcache DE Blanco3, David M Lucas2,4, H Liva Rakotondraibe3, Jimmy Orjala5, D Doel Soejarto5,6, Nicholas H Oberlies7, Cedric J Pearce8, Mansukh C Wani9, Brent R Stockwell10,11, Joanna E Burdette5, Steven M Swanson12, James R Fuchs3, Mitchell A Phelps3,2, Lihui Xu2, Xiaoli Zhang2,4, Young Yongchun Shen13.   

Abstract

Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested. Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity. Copyright
© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Entities:  

Keywords:  Natural products; cyanobacteria; fungi; potential anticancer activity; review; tropical plants

Mesh：

Substances：

Year:  2016        PMID： 27793884      PMCID： PMC5098703          DOI： 10.21873/anticanres.11146

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  94 in total

Review 1.  Bioactive microbial metabolites.

Authors:  János Bérdy
Journal:  J Antibiot (Tokyo)       Date:  2005-01       Impact factor: 2.649

2.  U.S. Food and Drug Administration approval summary: brentuximab vedotin for the treatment of relapsed Hodgkin lymphoma or relapsed systemic anaplastic large-cell lymphoma.

Authors:  R Angelo de Claro; Karen McGinn; Virginia Kwitkowski; Julie Bullock; Aakanksha Khandelwal; Bahru Habtemariam; Yanli Ouyang; Haleh Saber; Kyung Lee; Kallappa Koti; Mark Rothmann; Marjorie Shapiro; Francisco Borrego; Kathleen Clouse; Xiao Hong Chen; Janice Brown; Lara Akinsanya; Robert Kane; Edvardas Kaminskas; Ann Farrell; Richard Pazdur
Journal:  Clin Cancer Res       Date:  2012-09-07       Impact factor: 12.531

3.  The natural product phyllanthusmin C enhances IFN-γ production by human NK cells through upregulation of TLR-mediated NF-κB signaling.

Authors:  Youcai Deng; Jianhong Chu; Yulin Ren; Zhijin Fan; Xiaotian Ji; Bethany Mundy-Bosse; Shunzong Yuan; Tiffany Hughes; Jianying Zhang; Baljash Cheema; Andrew T Camardo; Yong Xia; Lai-Chu Wu; Li-Shu Wang; Xiaoming He; A Douglas Kinghorn; Xiaohui Li; Michael A Caligiuri; Jianhua Yu
Journal:  J Immunol       Date:  2014-08-13       Impact factor: 5.422

Review 4.  Trabectedin for the treatment of soft tissue sarcomas.

Authors:  Rita De Sanctis; Andrea Marrari; Armando Santoro
Journal:  Expert Opin Pharmacother       Date:  2016-07-04       Impact factor: 3.889

5.  Relationships between inhibitory activity against a cancer cell line panel, profiles of plants collected, and compound classes isolated in an anticancer drug discovery project.

Authors:  Marcy J Balunas; William P Jones; Young-Won Chin; Qiuwen Mi; Norman R Farnsworth; Djaja D Soejarto; Geoffrey A Cordell; Steven M Swanson; John M Pezzuto; Hee-Byung Chai; A Douglas Kinghorn
Journal:  Chem Biodivers       Date:  2006-08       Impact factor: 2.408

6.  Chemical Diversity of Metabolites from Fungi, Cyanobacteria, and Plants Relative to FDA-Approved Anticancer Agents.

Authors:  Tamam El-Elimat; Xiaoli Zhang; David Jarjoura; Franklin J Moy; Jimmy Orjala; A Douglas Kinghorn; Cedric J Pearce; Nicholas H Oberlies
Journal:  ACS Med Chem Lett       Date:  2012-07-12       Impact factor: 4.345

7.  Isolation, structure elucidation, and biological evaluation of 16,23-epoxycucurbitacin constituents from Eleaocarpus chinensis.

Authors:  Li Pan; Yeonjoong Yong; Ye Deng; Daniel D Lantvit; Tran Ngoc Ninh; Heebyung Chai; Esperanza J Carcache de Blanco; Djaja D Soejarto; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2012-01-12       Impact factor: 4.050

8.  Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities.

Authors:  Sloan Ayers; Brandie M Ehrmann; Audrey F Adcock; David J Kroll; Esperanza J Carcache de Blanco; Qi Shen; Steven M Swanson; Joseph O Falkinham; Mansukh C Wani; Sheila M Mitchell; Cedric J Pearce; Nicholas H Oberlies
Journal:  J Pept Sci       Date:  2012-06-29       Impact factor: 1.905

9.  Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia.

Authors:  Houda Alachkar; Ramasamy Santhanam; Jason G Harb; David M Lucas; Joshua J Oaks; Christopher J Hickey; Li Pan; A Douglas Kinghorn; Michael A Caligiuri; Danilo Perrotti; John C Byrd; Ramiro Garzon; Michael R Grever; Guido Marcucci
Journal:  J Hematol Oncol       Date:  2013-03-16       Impact factor: 17.388

10.  Potent cytotoxic arylnaphthalene lignan lactones from Phyllanthus poilanei.

Authors:  Yulin Ren; Daniel D Lantvit; Youcai Deng; Ragu Kanagasabai; Judith C Gallucci; Tran Ngoc Ninh; Hee-Byung Chai; Djaja D Soejarto; James R Fuchs; Jack C Yalowich; Jianhua Yu; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2014-06-12       Impact factor: 4.050
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  36 in total

1.  In situ mass spectrometry monitoring of fungal cultures led to the identification of four peptaibols with a rare threonine residue.

Authors:  Vincent P Sica; Evan R Rees; Huzefa A Raja; José Rivera-Chávez; Joanna E Burdette; Cedric J Pearce; Nicholas H Oberlies
Journal:  Phytochemistry       Date:  2017-07-31       Impact factor: 4.072

Review 2.  Current status and contemporary approaches to the discovery of antitumor agents from higher plants.

Authors:  Garima Agarwal; Peter J Blanco Carcache; Ermias Mekuria Addo; A Douglas Kinghorn
Journal:  Biotechnol Adv       Date:  2019-01-08       Impact factor: 14.227

3.  Potential Anticancer Agents Characterized from Selected Tropical Plants.

Authors:  Yulin Ren; Esperanza J Carcache de Blanco; James R Fuchs; Djaja D Soejarto; Joanna E Burdette; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2019-03-04       Impact factor: 4.050

4.  Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas.

Authors:  Long-Sheng Chang; Janet L Oblinger; Sarah S Burns; Jie Huang; Larry W Anderson; Melinda G Hollingshead; Rulong Shen; Li Pan; Garima Agarwal; Yulin Ren; Ryan D Roberts; Barry R O'Keefe; A Douglas Kinghorn; Jerry M Collins
Journal:  Mol Cancer Ther       Date:  2019-12-17       Impact factor: 6.261

5.  New tricks for old dogs: Two new macrocyclic trichothecene epimers and absolute configuration of 16-hydroxyverrucarin B.

Authors:  Diana Kao; Laura Flores-Bocanegra; Huzefa A Raja; Blaise A Darveaux; Cedric J Pearce; Nicholas H Oberlies
Journal:  Phytochemistry       Date:  2020-01-10       Impact factor: 4.072

6.  Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives.

Authors:  Yulin Ren; Gerardo D Anaya-Eugenio; Austin A Czarnecki; Tran Ngoc Ninh; Chunhua Yuan; Hee-Byung Chai; Djaja D Soejarto; Joanna E Burdette; Esperanza J Carcache de Blanco; A Douglas Kinghorn
Journal:  Bioorg Med Chem       Date:  2018-07-17       Impact factor: 3.641

7.  Crystal Structures and Human Leukemia Cell Apoptosis Inducible Activities of Parthenolide Analogues Isolated from Piptocoma rufescens.

Authors:  Yulin Ren; Judith C Gallucci; Xinxin Li; Lichao Chen; Jianhua Yu; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2018-01-19       Impact factor: 4.050

8.  The comparison of miRNAs that respond to anti-breast cancer drugs and usnic acid for the treatment of breast cancer.

Authors:  Demet Cansaran-Duman; Ümmügülsüm Tanman; Sevcan Yangın; Orhan Atakol
Journal:  Cytotechnology       Date:  2020-10-30       Impact factor: 2.058

9.  Na+/K+-ATPase-Targeted Cytotoxicity of (+)-Digoxin and Several Semisynthetic Derivatives.

Authors:  Yulin Ren; Hennrique T Ribas; Kimberly Heath; Sijin Wu; Jinhong Ren; Pratik Shriwas; Xiaozhuo Chen; Michael E Johnson; Xiaolin Cheng; Joanna E Burdette; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2020-02-25       Impact factor: 4.050

10.  Revisiting the linkage between ethnomedical use and development of new medicines: A novel plant collection strategy towards the discovery of anticancer agents.

Authors:  Joshua M Henkin; Kongmany Sydara; Mouachanh Xayvue; Onevilay Souliya; A Douglas Kinghorn; Joanna E Burdette; Wei-Lun Chen; Bethany G Elkington; Djaja D Soejarto
Journal:  J Med Plant Res       Date:  2017-10-25
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