Literature DB >> 23193103

Synthesis, duplex stabilization and structural properties of a fluorinated carbocyclic LNA analogue.

Punit P Seth1, Pradeep S Pallan, Eric E Swayze, Martin Egli.   

Abstract

DNA oligonucleotides modified with nucleoside monomers which have an electron withdrawing group (EWG) at the 2'-position of the furanose ring form more stable duplexes with complementary RNA as compared to unmodified DNA. Here we show that an anti-periplanar orientation of the nucleobase and the 2'-EWG is important for optimal duplex stabilization even for nucleic acid analogues with conformationally locked furanose rings.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23193103      PMCID： PMC3684079          DOI： 10.1002/cbic.201200669

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  21 in total

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Authors:  M Egli; N Usman; A Rich
Journal:  Biochemistry       Date:  1993-04-06       Impact factor: 3.162

7.  Convenient synthesis of fluorinated nucleosides with perfluoroalkanesulfonyl fluorides.

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Journal:  Nucleosides Nucleotides Nucleic Acids       Date:  2002 Nov-Dec       Impact factor: 1.381

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Journal:  J Org Chem       Date:  2009-09-04       Impact factor: 4.354

9.  Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility.

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10.  Potent inhibition of microRNA in vivo without degradation.

Authors:  Scott Davis; Stephanie Propp; Susan M Freier; Laura E Jones; Martin J Serra; Garth Kinberger; Balkrishen Bhat; Eric E Swayze; C Frank Bennett; Christine Esau
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