BACKGROUND AND OBJECTIVES: Disease-specific survival (DSS) for GC patients differs in Eastern and Western countries. The aim is to compare outcomes of US and Korean patients following resection of early-stage, node-negative gastric carcinoma (GC). METHODS: All patients (1995-2005) with T1N0 gastric carcinoma, excluding gastroesophageal tumors, were evaluated. DSS was compared by adjusting for prognostic variables from an internationally validated GC nomogram. RESULTS: The cohort included 598 Korean patients and 159 US patients. Age and BMI were significantly higher in US patients. Distal tumor location was more frequent in Korea (60% vs. 52%) and proximal location in the US (19% vs. 5%, P < 0.0001). Five-year DSS did not differ significantly between Korea and the US. After multivariate analysis, DSS of Korean patients persisted, with no significant differences when compared to US patients (HR = 1.2, 95% CI: 0.3-5.2, P = 0.83). CONCLUSIONS: Despite widespread speculations that GC differs in the East and West, when we compare similarly staged, node-negative GC patients, survival did not differ significantly between Korea and the US. This suggests that GC is a heterogeneous disease and when similar subtypes of gastric cancer are compared, these differences disappear. This study suggests more similarities than previously hypothesized between US and Korean GC patients.
BACKGROUND AND OBJECTIVES: Disease-specific survival (DSS) for GC patients differs in Eastern and Western countries. The aim is to compare outcomes of US and Korean patients following resection of early-stage, node-negative gastric carcinoma (GC). METHODS: All patients (1995-2005) with T1N0 gastric carcinoma, excluding gastroesophageal tumors, were evaluated. DSS was compared by adjusting for prognostic variables from an internationally validated GC nomogram. RESULTS: The cohort included 598 Korean patients and 159 US patients. Age and BMI were significantly higher in US patients. Distal tumor location was more frequent in Korea (60% vs. 52%) and proximal location in the US (19% vs. 5%, P < 0.0001). Five-year DSS did not differ significantly between Korea and the US. After multivariate analysis, DSS of Korean patients persisted, with no significant differences when compared to US patients (HR = 1.2, 95% CI: 0.3-5.2, P = 0.83). CONCLUSIONS: Despite widespread speculations that GC differs in the East and West, when we compare similarly staged, node-negative GC patients, survival did not differ significantly between Korea and the US. This suggests that GC is a heterogeneous disease and when similar subtypes of gastric cancer are compared, these differences disappear. This study suggests more similarities than previously hypothesized between US and Korean GC patients.
Authors: Vivian E Strong; Kyo Young Song; Cho Hyun Park; Lindsay M Jacks; Mithat Gonen; Manish Shah; Daniel G Coit; Murray F Brennan Journal: Ann Surg Date: 2010-04 Impact factor: 12.969
Authors: Shinichi Fukuhara; Mariko Yabe; Marissa M Montgomery; Shinobu Itagaki; Steven T Brower; Martin S Karpeh Journal: J Gastrointest Surg Date: 2014-07-25 Impact factor: 3.452
Authors: Vivian E Strong; Ai-Wen Wu; Luke V Selby; Mithat Gonen; Meier Hsu; Kyo Young Song; Cho Hyun Park; Daniel G Coit; Jia-Fu Ji; Murray F Brennan Journal: J Surg Oncol Date: 2015-07-14 Impact factor: 3.454
Authors: Elfriede Bollschweiler; Felix Berlth; Christoph Baltin; Stefan Mönig; Arnulf H Hölscher Journal: World J Gastroenterol Date: 2014-05-21 Impact factor: 5.742
Authors: Carmen L Mueller; Robert Lisbona; Rafik Sorial; Aya Siblini; Lorenzo E Ferri Journal: J Gastrointest Surg Date: 2019-03-11 Impact factor: 3.452
Authors: A L Mahar; A El-Sedfy; M Dixon; M Siddiqui; M Elmi; A Ritter; J Vasilevska-Ristovska; Y Jeong; L Helyer; C Law; B Zagorski; N G Coburn Journal: Curr Oncol Date: 2018-10-31 Impact factor: 3.677
Authors: Siraj M Ali; Eric M Sanford; Samuel J Klempner; Douglas A Rubinson; Kai Wang; Norma A Palma; Juliann Chmielecki; Roman Yelensky; Gary A Palmer; Deborah Morosini; Doron Lipson; Daniel V Catenacci; Fadi Braiteh; Rachel Erlich; Philip J Stephens; Jeffrey S Ross; Sai-Hong Ignatius Ou; Vincent A Miller Journal: Oncologist Date: 2015-04-16
Authors: Liang Cao; Luke V Selby; Xiang Hu; Yi Zhang; Yelena Y Janjigian; Laura Tang; Daniel G Coit; Murray F Brennan; Vivian E Strong Journal: J Surg Oncol Date: 2016-04-04 Impact factor: 3.454