PURPOSE: The development of nonradioactive and targeted magnetonanoparticles (MNP) capable of crossing the blood-brain barrier (BBB) and of concentrating in and enhancing the contrast of intracranial tumors on magnetic resonance imaging (MRI). PROCEDURE: Nonradioactive 2-deoxy-D-glucose (2DG) was covalently attached to magnetonanoparticles composed of iron oxide and dextran and prepared for intravenous (tail) injection in the naïve rats and mouse models of glioma. MR images were acquired at 3 and 7 T. RESULTS: 2DG-MNP increased tumor visibility and improved delineation of tumor margins. Histopathology confirmed that 2DG-MNP crossed the BBB and accumulated within brain parenchyma. CONCLUSION: Nonradioactive 2DG-MNP can cross an intact BBB on and improve visualization of tumor and tumor margins on MRI.
PURPOSE: The development of nonradioactive and targeted magnetonanoparticles (MNP) capable of crossing the blood-brain barrier (BBB) and of concentrating in and enhancing the contrast of intracranial tumors on magnetic resonance imaging (MRI). PROCEDURE: Nonradioactive 2-deoxy-D-glucose (2DG) was covalently attached to magnetonanoparticles composed of iron oxide and dextran and prepared for intravenous (tail) injection in the naïve rats and mouse models of glioma. MR images were acquired at 3 and 7 T. RESULTS:2DG-MNP increased tumor visibility and improved delineation of tumor margins. Histopathology confirmed that 2DG-MNP crossed the BBB and accumulated within brain parenchyma. CONCLUSION: Nonradioactive 2DG-MNP can cross an intact BBB on and improve visualization of tumor and tumor margins on MRI.
Authors: Bulent Aydogan; Ji Li; Tijana Rajh; Ahmed Chaudhary; Steven J Chmura; Charles Pelizzari; Christian Wietholt; Metin Kurtoglu; Peter Redmond Journal: Mol Imaging Biol Date: 2010-10 Impact factor: 3.488
Authors: M J van den Bent; J S Wefel; D Schiff; M J B Taphoorn; K Jaeckle; L Junck; T Armstrong; A Choucair; A D Waldman; T Gorlia; M Chamberlain; B G Baumert; M A Vogelbaum; D R Macdonald; D A Reardon; P Y Wen; S M Chang; A H Jacobs Journal: Lancet Oncol Date: 2011-04-05 Impact factor: 41.316
Authors: Yoshimi Anzai; Catherine W Piccoli; Eric K Outwater; William Stanford; David A Bluemke; Pamela Nurenberg; Sanjay Saini; Kenneth R Maravilla; David E Feldman; Udo P Schmiedl; James A Brunberg; Isaac R Francis; Steven E Harms; Peter M Som; Clare M Tempany Journal: Radiology Date: 2003-09 Impact factor: 11.105