Literature DB >> 23179974

Dose response and structural injury in the disability of spinal injury.

Mohammed Shakil Patel1, Philip Sell.   

Abstract

INTRODUCTION: In traumatic injury there is a clear relationship between the dose of energy involved, structural tissue damage and resultant disability after recovery. This relationship is often absent in cases of non-specific chronic low back pain that is perceived by patients as attributed to a workplace injury. There are many studies assessing risk factors for non-specific low back pain. However, studies addressing causality of back pain are deficient.
PURPOSE: To establish whether there exists a causal relationship between structural injury, low back pain and spinal disability.
METHODS: Retrospective analysis of prospectively gathered validated spinal outcome measures [Oswestry disability index (ODI), low back outcome score (LBO), modified somatic perception (MSP), modified Zung depression index (MZD)] between patients with healed high energy thoracolumbar spinal fractures and patients with self-perceived work-related low back pain. Causality was established according to two of Bradford Hill's criteria of medical causality, temporal and dose-response relationships.
RESULTS: Twenty-three patients with spinal fractures (group 1) of average age 44 years were compared to 19 patients with self-reported back pain in the workplace pursuing claims for compensation (group 2) of average age 48 years. Both groups were comparable in terms of age and sex. The average ODI in group 1 was 28 % (SD 19) compared to 42 % (SD 19) in group 2 (P < 0.05). Similarly, LBOS was 39.7 versus 24.3 (P < 0.05), MSP 4.3 versus 9.3 (P < 0.05) and MZD 20.2 versus 34.8 (P < 0.05) in groups 1 and 2, respectively.
CONCLUSION: Despite high-energy trauma and significant structural damage to the spine, patients with the high energy injuries had better spinal outcome scores in all measures. There is no 'dose-response' relationship between structural injury, low back pain and spinal disability. This is the reverse of what would be anticipated if structural injury was the cause of disability in workplace reported onset of low back pain.

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Year:  2012        PMID: 23179974      PMCID: PMC3585642          DOI: 10.1007/s00586-012-2498-2

Source DB:  PubMed          Journal:  Eur Spine J        ISSN: 0940-6719            Impact factor:   3.134


  23 in total

Review 1.  Prognostic values of physical examination findings in patients with chronic low back pain treated conservatively: a systematic literature review.

Authors:  J A Borge; C Leboeuf-Yde; J Lothe
Journal:  J Manipulative Physiol Ther       Date:  2001-05       Impact factor: 1.437

2.  Outcome of low back pain in general practice: a prospective study.

Authors:  P R Croft; G J Macfarlane; A C Papageorgiou; E Thomas; A J Silman
Journal:  BMJ       Date:  1998-05-02

3.  Functional outcome of low lumbar burst fractures. A multicenter review of operative and nonoperative treatment of L3-L5.

Authors:  E A Seybold; C A Sweeney; B E Fredrickson; L G Warhold; P M Bernini
Journal:  Spine (Phila Pa 1976)       Date:  1999-10-15       Impact factor: 3.468

Review 4.  [Diagnostic assessment in lumbar back pain. I. Anamnesis and clinical examination].

Authors:  N Boos; R Kissling
Journal:  Praxis (Bern 1994)       Date:  1999-02-18

5.  Functional and radiographic outcome of thoracolumbar and lumbar burst fractures managed by closed orthopaedic reduction and casting.

Authors:  Patrick Tropiano; Russel C Huang; Christian A Louis; Dominique G Poitout; Rene P Louis
Journal:  Spine (Phila Pa 1976)       Date:  2003-11-01       Impact factor: 3.468

6.  Operative compared with nonoperative treatment of a thoracolumbar burst fracture without neurological deficit. A prospective, randomized study.

Authors:  K Wood; G Buttermann; G Butterman; A Mehbod; T Garvey; R Jhanjee; V Sechriest
Journal:  J Bone Joint Surg Am       Date:  2003-05       Impact factor: 5.284

7.  Outcomes after injury: a comparison of workplace and nonworkplace injury.

Authors:  Suzanne Mason; Jim Wardrope; Graham Turpin; Alison Rowlands
Journal:  J Trauma       Date:  2002-07

8.  Functional outcomes after surgery for spinal fractures: return to work and activity.

Authors:  Robert F McLain
Journal:  Spine (Phila Pa 1976)       Date:  2004-02-15       Impact factor: 3.468

9.  A prospective study of low back pain in a general population. I. Occurrence, recurrence and aetiology.

Authors:  F Biering-Sørensen
Journal:  Scand J Rehabil Med       Date:  1983

10.  Prediction of chronic disability in work-related musculoskeletal disorders: a prospective, population-based study.

Authors:  Judith A Turner; Gary Franklin; Deborah Fulton-Kehoe; Kathleen Egan; Thomas M Wickizer; James F Lymp; Lianne Sheppard; Joel D Kaufman
Journal:  BMC Musculoskelet Disord       Date:  2004-05-24       Impact factor: 2.362

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  1 in total

Review 1.  The Michel Benoist and Robert Mulholland Yearly European Spine Journal Review: a survey of the "surgical and research" articles in the European Spine Journal, 2013.

Authors:  Robert C Mulholland
Journal:  Eur Spine J       Date:  2014-01-03       Impact factor: 3.134

  1 in total

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