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Literature DB >> 23174300

Transcription: base J blocks the way.

Abstract

How do cells stop transcribing RNA Polymerase II to promote proper gene expression and prevent transcriptional havoc in the genome? In the case of Leishmania, a uniquely modified DNA base blocks RNA Polymerase II and suggests an interesting new model for transcription termination.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 23174300 PMCID： PMC3648658 DOI： 10.1016/j.cub.2012.10.010

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

20 in total

1. CTD-dependent dismantling of the RNA polymerase II elongation complex by the pre-mRNA 3'-end processing factor, Pcf11.

Authors: Zhiqiang Zhang; Jianhua Fu; David S Gilmour
Journal: Genes Dev Date: 2005-07-01 Impact factor: 11.361

Review 2. The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs.

Authors: Alain Jacquier
Journal: Nat Rev Genet Date: 2009-12 Impact factor: 53.242

Review 3. Keeping up to speed with the transcription termination factor Rho motor.

Authors: Marc Boudvillain; Marcello Nollmann; Emmanuel Margeat
Journal: Transcription Date: 2010 Sep-Oct

Review 4. Unravelling the means to an end: RNA polymerase II transcription termination.

Authors: Jason N Kuehner; Erika L Pearson; Claire Moore
Journal: Nat Rev Mol Cell Biol Date: 2011-04-13 Impact factor: 94.444

5. Sen-sing RNA terminators.

Authors: David A Brow
Journal: Mol Cell Date: 2011-06-24 Impact factor: 17.970

6. Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

Authors: Henri G A M van Luenen; Carol Farris; Sabrina Jan; Paul-Andre Genest; Pankaj Tripathi; Arno Velds; Ron M Kerkhoven; Marja Nieuwland; Andrew Haydock; Gowthaman Ramasamy; Saara Vainio; Tatjana Heidebrecht; Anastassis Perrakis; Ludo Pagie; Bas van Steensel; Peter J Myler; Piet Borst
Journal: Cell Date: 2012-08-31 Impact factor: 41.582

Transcription: base J blocks the way.

1. CTD-dependent dismantling of the RNA polymerase II elongation complex by the pre-mRNA 3'-end processing factor, Pcf11.

Review 2. The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs.

Review 3. Keeping up to speed with the transcription termination factor Rho motor.

Review 4. Unravelling the means to an end: RNA polymerase II transcription termination.

5. Sen-sing RNA terminators.

6. Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

7. The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II.

8. Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.

Review 9. Lights and shadows on gene organization and regulation of gene expression in Leishmania.

Review 10. Transcription-coupled DNA repair: two decades of progress and surprises.

1. J-binding protein 1 and J-binding protein 2 expression in clinical Leishmania major no response-antimonial isolates.