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Literature DB >> 23159836

The transcriptional regulator lola is required for stem cell maintenance and germ cell differentiation in the Drosophila testis.

Erin L Davies¹, Jaclyn G Y Lim, William J Joo, Cheuk Ho Tam, Margaret T Fuller.

Abstract

Stem cell behavior is regulated by extrinsic signals from specialized microenvironments, or niches, and intrinsic factors required for execution of context-appropriate responses to niche signals. Here we show that function of the transcriptional regulator longitudinals lacking (lola) is required cell autonomously for germline stem cell and somatic cyst stem cell maintenance in the Drosophila testis. In addition, lola is also required for proper execution of key developmental transitions during male germ cell differentiation, including the switch from transit amplifying progenitor to spermatocyte growth and differentiation, as well as meiotic cell cycle progression and spermiogenesis. Different lola isoforms, each having unique C-termini and zinc finger domains, may control different aspects of proliferation and differentiation in the male germline and somatic cyst stem cell lineages.

Entities: Chemical Disease Gene Mutation Species

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Year: 2012 PMID： 23159836 PMCID： PMC4006830 DOI： 10.1016/j.ydbio.2012.11.004

Source DB: PubMed Journal: Dev Biol ISSN： 0012-1606 Impact factor: 3.582

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