Literature DB >> 23159569

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor.

Jong Yeon Hwang1, Marc Peter Windisch, Suyeon Jo, Keumhyun Kim, Sunju Kong, Hyoung Cheul Kim, Soohyun Kim, Heeyoung Kim, Myung Eun Lee, Youngmi Kim, Jihyun Choi, Dong-Sik Park, Eunjung Park, Jeongjin Kwon, Jiyoun Nam, Sujin Ahn, Jonathan Cechetto, Junwon Kim, Michel Liuzzi, Zaesung No, Jinhwa Lee.   

Abstract

We describe a novel 7-aminopyrazolo[1,5-a]pyrimidine (7-APP) derivative as a potent hepatitis C virus (HCV) inhibitor. A series of 7-APPs was synthesized and evaluated for inhibitory activity against HCV in different cell culture systems. The synthesis and preliminary structure-activity relationship study of 7-APP are reported.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23159569     DOI： 10.1016/j.bmcl.2012.10.123

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Efficient microwave-assisted Suzuki-Miyaura cross-coupling reaction of 3-bromo pyrazolo[1,5-a]pyrimidin-5(4H)-one: towards a new access to 3,5-diarylated 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine derivatives.

Authors:  Badr Jismy; Gérald Guillaumet; Mohamed Akssira; Abdellatif Tikad; Mohamed Abarbri
Journal:  RSC Adv       Date:  2021-01-04       Impact factor: 4.036

2.  Parallel synthesis of 7-heteroaryl-pyrazolo[1,5-a]pyrimidine-3-carboxamides.

Authors:  Sizana Ahmetaj; Nina Velikanje; Uroš Grošelj; Ines Šterbal; Benjamin Prek; Amalija Golobič; Drago Kočar; Georg Dahmann; Branko Stanovnik; Jurij Svete
Journal:  Mol Divers       Date:  2013-08-22       Impact factor: 2.943

3.  Catalyst-Switchable Regiocontrol in the Direct Arylation of Remote C-H Groups in Pyrazolo[1,5-a]pyrimidines.

Authors:  Robin B Bedford; Steven J Durrant; Michelle Montgomery
Journal:  Angew Chem Int Ed Engl       Date:  2015-06-10       Impact factor: 15.336

4.  Synthesis of pyrazolopyrimidinones using a "one-pot" approach under microwave irradiation.

Authors:  Mark Kelada; John M D Walsh; Robert W Devine; Patrick McArdle; John C Stephens
Journal:  Beilstein J Org Chem       Date:  2018-05-28       Impact factor: 2.883

5.  Efficient Access to 3,5-Disubstituted 7-(Trifluoromethyl)pyrazolo[1,5-a]pyrimidines Involving SNAr and Suzuki Cross-Coupling Reactions.

Authors:  Badr Jismy; Abdellatif Tikad; Mohamed Akssira; Gérald Guillaumet; Mohamed Abarbri
Journal:  Molecules       Date:  2020-04-28       Impact factor: 4.411

6.  An efficient and targeted synthetic approach towards new highly substituted 6-amino-pyrazolo[1,5-a]pyrimidines with α-glucosidase inhibitory activity.

Authors:  Fariba Peytam; Mehdi Adib; Reihaneh Shourgeshty; Loghman Firoozpour; Mahmoud Rahmanian-Jazi; Mehdi Jahani; Setareh Moghimi; Kouros Divsalar; Mohammad Ali Faramarzi; Somayeh Mojtabavi; Fatemeh Safari; Mohammad Mahdavi; Alireza Foroumadi
Journal:  Sci Rep       Date:  2020-02-13       Impact factor: 4.379

7.  Synthesis and Antimicrobial Evaluation of Novel Pyrazolopyrimidines Incorporated with Mono- and Diphenylsulfonyl Groups.

Authors:  Amani M R Alsaedi; Thoraya A Farghaly; Mohamed R Shaaban
Journal:  Molecules       Date:  2019-11-05       Impact factor: 4.411

8.  Structure-Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents.

Authors:  Sangmi Oh; M Daben J Libardo; Shaik Azeeza; Gary T Pauly; Jose Santinni O Roma; Andaleeb Sajid; Yoshitaka Tateishi; Caroline Duncombe; Michael Goodwin; Thomas R Ioerger; Paul G Wyatt; Peter C Ray; David W Gray; Helena I M Boshoff; Clifton E Barry
Journal:  ACS Infect Dis       Date:  2021-01-06       Impact factor: 5.084

9.  Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase.

Authors:  Sungjin Lee; Kee Dong Yoon; Myungeun Lee; Yoojin Cho; Gahee Choi; Hongje Jang; BeomSeok Kim; Da-Hee Jung; Jin-Gyo Oh; Geon-Woo Kim; Jong-Won Oh; Yong-Joo Jeong; Ho Jeong Kwon; Soo Kyung Bae; Dal-Hee Min; Marc P Windisch; Tae-Hwe Heo; Choongho Lee
Journal:  Br J Pharmacol       Date:  2015-11-25       Impact factor: 8.739

10.  Plant-Derived Purification, Chemical Synthesis, and In Vitro/In Vivo Evaluation of a Resveratrol Dimer, Viniferin, as an HCV Replication Inhibitor.

Authors:  Sungjin Lee; Karabasappa Mailar; Mi Il Kim; Minkyung Park; Jiseon Kim; Dal-Hee Min; Tae-Hwe Heo; Soo Kyung Bae; Wonjun Choi; Choongho Lee
Journal:  Viruses       Date:  2019-09-23       Impact factor: 5.048
  10 in total

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