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Literature DB >> 23158586

A phenotypic screening platform to identify small molecule modulators of Chlamydomonas reinhardtii growth, motility and photosynthesis.

Simon E Alfred, Anuradha Surendra, Chris Le, Ken Lin, Alexander Mok, Iain M Wallace, Michael Proctor, Malene L Urbanus, Guri Giaever, Corey Nislow.

Abstract

Chemical biology, the interfacial discipline of using small molecules as probes to investigate biology, is a powerful approach of developing specific, rapidly acting tools that can be applied across organisms. The single-celled alga Chlamydomonas reinhardtii is an excellent model system because of its photosynthetic ability, cilia-related motility and simple genetics. We report the results of an automated fitness screen of 5,445 small molecules and subsequent assays on motility/phototaxis and photosynthesis. Cheminformatic analysis revealed active core structures and was used to construct a naïve Bayes model that successfully predicts algal bioactive compounds.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 23158586 PMCID： PMC3580497 DOI： 10.1186/gb-2012-13-11-r105

Source DB: PubMed Journal: Genome Biol ISSN： 1474-7596 Impact factor: 13.583

58 in total

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3 in total