Literature DB >> 2314900

Overexpression confers an oncogenic potential upon the eph gene.

Y Maru1, H Hirai, F Takaku.   

Abstract

The eph gene encodes a putative receptor tyrosine kinase for an as yet unknown ligand. Some human cancer cells have been found to overexpress eph mRNAs without gene amplification. We show here that NIH3T3 cells acquire tumorigenic ability in nude mice and make colonies in soft agar with a viral LTR (Long Terminal Repeat)-driven artificial expression of the eph gene to a high level. This result supports the alleged contribution of overexpressed receptor tyrosine kinases to cell transformation.

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Year:  1990        PMID： 2314900

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  25 in total

1.  Eph receptor and mTOR pathway crosstalk: implications for cancer.

Authors:  Mustafa Sahin
Journal:  Cell Cycle       Date:  2010-06-01       Impact factor: 4.534

Review 2.  Eph receptors and ephrins in cancer: bidirectional signalling and beyond.

Authors:  Elena B Pasquale
Journal:  Nat Rev Cancer       Date:  2010-03       Impact factor: 60.716

3.  cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases.

Authors:  R A Lindberg; T Hunter
Journal:  Mol Cell Biol       Date:  1990-12       Impact factor: 4.272

4.  Decreased expression of EphA5 is associated with Fuhrman nuclear grade and pathological tumour stage in ccRCC.

Authors:  Xiaolin Wang; Haifei Xu; Zhijun Wu; Xiao Chen; Jiandong Wang
Journal:  Int J Exp Pathol       Date:  2017-04-19       Impact factor: 1.925

5.  Identification of chicken embryo kinase 5, a developmentally regulated receptor-type tyrosine kinase of the Eph family.

Authors:  E B Pasquale
Journal:  Cell Regul       Date:  1991-07

6.  Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells.

Authors:  Zheng-Long Yuan; Ying-Jie Guan; Lijuan Wang; Wenyi Wei; Agnes B Kane; Y Eugene Chin
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

7.  EPHA7 and EPHA10 Physically Interact and Differentially Co-localize in Normal Breast and Breast Carcinoma Cell Lines, and the Co-localization Pattern Is Altered in EPHB6-expressing MDA-MB-231 Cells.

Authors:  Candace Johnson; Briana Segovia; Raj P Kandpal
Journal:  Cancer Genomics Proteomics       Date:  2016 09-10       Impact factor: 4.069

8.  Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis.

Authors:  Birgit Mosch; Bettina Reissenweber; Christin Neuber; Jens Pietzsch
Journal:  J Oncol       Date:  2010-03-10       Impact factor: 4.375

9.  axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.

Authors:  J P O'Bryan; R A Frye; P C Cogswell; A Neubauer; B Kitch; C Prokop; R Espinosa; M M Le Beau; H S Earp; E T Liu
Journal:  Mol Cell Biol       Date:  1991-10       Impact factor: 4.272

10.  Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival.

Authors:  N I Herath; J Doecke; M D Spanevello; B A Leggett; A W Boyd
Journal:  Br J Cancer       Date:  2009-03-10       Impact factor: 7.640
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