Literature DB >> 20179713

Eph receptors and ephrins in cancer: bidirectional signalling and beyond.

Elena B Pasquale1.   

Abstract

The Eph receptor tyrosine kinases and their ephrin ligands have intriguing expression patterns in cancer cells and tumour blood vessels, which suggest important roles for their bidirectional signals in many aspects of cancer development and progression. Eph gene mutations probably also contribute to cancer pathogenesis. Eph receptors and ephrins have been shown to affect the growth, migration and invasion of cancer cells in culture as well as tumour growth, invasiveness, angiogenesis and metastasis in vivo. However, Eph signalling activities in cancer seem to be complex, and are characterized by puzzling dichotomies. Nevertheless, the Eph receptors are promising new therapeutic targets in cancer.

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Year:  2010        PMID： 20179713      PMCID： PMC2921274          DOI： 10.1038/nrc2806

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  226 in total

1.  Serrated carcinomas form a subclass of colorectal cancer with distinct molecular basis.

Authors:  P Laiho; A Kokko; S Vanharanta; R Salovaara; H Sammalkorpi; H Järvinen; J-P Mecklin; T J Karttunen; K Tuppurainen; V Davalos; S Schwartz; D Arango; M J Mäkinen; L A Aaltonen
Journal:  Oncogene       Date:  2006-07-03       Impact factor: 9.867

2.  Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motility.

Authors:  Alice Bjerregaard Larsen; Mikkel Wandahl Pedersen; Marie-Thérése Stockhausen; Michael Vibo Grandal; Bo van Deurs; Hans Skovgaard Poulsen
Journal:  Mol Cancer Res       Date:  2007-03       Impact factor: 5.852

3.  Ephrin-A1 expression contributes to the malignant characteristics of {alpha}-fetoprotein producing hepatocellular carcinoma.

Authors:  H Iida; M Honda; H F Kawai; T Yamashita; Y Shirota; B-C Wang; H Miao; S Kaneko
Journal:  Gut       Date:  2005-06       Impact factor: 23.059

4.  Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation.

Authors:  Guanglei Zhuang; Sonja Hunter; Yoonha Hwang; Jin Chen
Journal:  J Biol Chem       Date:  2006-11-29       Impact factor: 5.157

5.  Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection.

Authors:  Fei Huang; Karen Reeves; Xia Han; Craig Fairchild; Suso Platero; Tai W Wong; Francis Lee; Peter Shaw; Edwin Clark
Journal:  Cancer Res       Date:  2007-03-01       Impact factor: 12.701

6.  Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features.

Authors:  Ming Guan; Chong Xu; Fanglin Zhang; Chuanzhong Ye
Journal:  Int J Cancer       Date:  2009-01-01       Impact factor: 7.396

Review 7.  Paradoxes of the EphB4 receptor in cancer.

Authors:  Nicole K Noren; Elena B Pasquale
Journal:  Cancer Res       Date:  2007-05-01       Impact factor: 12.701

8.  Selective targeting and potent control of tumor growth using an EphA2/CD3-Bispecific single-chain antibody construct.

Authors:  Scott A Hammond; Ralf Lutterbuese; Shannon Roff; Petra Lutterbuese; Bernd Schlereth; Elizabeth Bruckheimer; Michael S Kinch; Steve Coats; Patrick A Baeuerle; Peter Kufer; Peter A Kiener
Journal:  Cancer Res       Date:  2007-04-15       Impact factor: 12.701

9.  Patterns of somatic mutation in human cancer genomes.

Authors:  Christopher Greenman; Philip Stephens; Raffaella Smith; Gillian L Dalgliesh; Christopher Hunter; Graham Bignell; Helen Davies; Jon Teague; Adam Butler; Claire Stevens; Sarah Edkins; Sarah O'Meara; Imre Vastrik; Esther E Schmidt; Tim Avis; Syd Barthorpe; Gurpreet Bhamra; Gemma Buck; Bhudipa Choudhury; Jody Clements; Jennifer Cole; Ed Dicks; Simon Forbes; Kris Gray; Kelly Halliday; Rachel Harrison; Katy Hills; Jon Hinton; Andy Jenkinson; David Jones; Andy Menzies; Tatiana Mironenko; Janet Perry; Keiran Raine; Dave Richardson; Rebecca Shepherd; Alexandra Small; Calli Tofts; Jennifer Varian; Tony Webb; Sofie West; Sara Widaa; Andy Yates; Daniel P Cahill; David N Louis; Peter Goldstraw; Andrew G Nicholson; Francis Brasseur; Leendert Looijenga; Barbara L Weber; Yoke-Eng Chiew; Anna DeFazio; Mel F Greaves; Anthony R Green; Peter Campbell; Ewan Birney; Douglas F Easton; Georgia Chenevix-Trench; Min-Han Tan; Sok Kean Khoo; Bin Tean Teh; Siu Tsan Yuen; Suet Yi Leung; Richard Wooster; P Andrew Futreal; Michael R Stratton
Journal:  Nature       Date:  2007-03-08       Impact factor: 49.962

10.  The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome.

Authors:  S R Kumar; R Masood; W A Spannuth; J Singh; J Scehnet; G Kleiber; N Jennings; M Deavers; V Krasnoperov; L Dubeau; F A Weaver; A K Sood; P S Gill
Journal:  Br J Cancer       Date:  2007-03-13       Impact factor: 7.640
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  521 in total

1.  Transcriptional regulation of the protocadherin β cluster during Her-2 protein-induced mammary tumorigenesis results from altered N-glycan branching.

Authors:  Huabei Guo; Alison Nairn; Mitche dela Rosa; Tamas Nagy; Shaying Zhao; Kelley Moremen; Michael Pierce
Journal:  J Biol Chem       Date:  2012-06-04       Impact factor: 5.157

2.  Cancer cells exploit the Eph-ephrin system to promote invasion and metastasis: tales of unwitting partners.

Authors:  Bingcheng Wang
Journal:  Sci Signal       Date:  2011-05-31       Impact factor: 8.192

3.  Eph/ephrin interactions modulate muscle satellite cell motility and patterning.

Authors:  Danny A Stark; Rowan M Karvas; Ashley L Siegel; D D W Cornelison
Journal:  Development       Date:  2011-11-09       Impact factor: 6.868

4.  Effect of ephrin-A1/EphA2 on invasion of trophoblastic cells.

Authors:  Yun Yang; Jie Min
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2011-12-16

Review 5.  Targeting Eph receptors with peptides and small molecules: progress and challenges.

Authors:  Roberta Noberini; Ilaria Lamberto; Elena B Pasquale
Journal:  Semin Cell Dev Biol       Date:  2011-10-25       Impact factor: 7.727

Review 6.  Chemistry and biology of multicomponent reactions.

Authors:  Alexander Dömling; Wei Wang; Kan Wang
Journal:  Chem Rev       Date:  2012-03-22       Impact factor: 60.622

7.  Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer.

Authors:  Arun R Pandiri; Robert C Sills; Vincent Ziglioli; Thai-Vu T Ton; Hue-Hua L Hong; Stephanie A Lahousse; Kevin E Gerrish; Scott S Auerbach; Keith R Shockley; Pierre R Bushel; Shyamal D Peddada; Mark J Hoenerhoff
Journal:  Toxicol Pathol       Date:  2012-06-11       Impact factor: 1.902

Review 8.  Spatial organization of transmembrane receptor signalling.

Authors:  Ioanna Bethani; Sigrid S Skånland; Ivan Dikic; Amparo Acker-Palmer
Journal:  EMBO J       Date:  2010-08-18       Impact factor: 11.598

9.  Truncated EphA2 likely potentiates cell adhesion via integrins as well as infiltration and/or lodgment of a monocyte/macrophage cell line in the red pulp and marginal zone of the mouse spleen, where ephrin-A1 is prominently expressed in the vasculature.

Authors:  Naoko Konda; Noritaka Saeki; Shingo Nishino; Kazushige Ogawa
Journal:  Histochem Cell Biol       Date:  2016-09-24       Impact factor: 4.304

10.  Erythropoietin-producing hepatocellular A6 overexpression is a novel biomarker of poor prognosis in patients with breast cancer.

Authors:  Danmei Zhou; Kehan Ren; Jigang Wang; Hong Ren; Wenlin Yang; Wenjuan Wang; Qiong Li; Xiuping Liu; Feng Tang
Journal:  Oncol Lett       Date:  2018-02-01       Impact factor: 2.967
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