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Literature DB >> 23146768

Aging and reprogramming: a two-way street.

Abstract

Aging is accompanied by the functional decline of cells, tissues, and organs, as well as a striking increase in a wide range of diseases. The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) opens new avenues for the aging field and has important applications for therapeutic treatments of age-related diseases. Here we review emerging studies on how aging and age-related pathways influence iPSC generation and property. We discuss the exciting possibility that reverting to a pluripotent stem cell stage erases several deficits associated with aging and offers new strategies for rejuvenation. Finally, we argue that reprogramming provides a unique opportunity to model aging and perhaps exceptional longevity.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Year: 2012 PMID： 23146768 PMCID： PMC3540161 DOI： 10.1016/j.ceb.2012.10.004

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

114 in total

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Journal: Nature Date: 2010-03-25 Impact factor: 49.962

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Authors: Pollyanna Agnes Tat; Huseyin Sumer; Daniele Pralong; Paul John Verma
Journal: Cell Reprogram Date: 2011-07-05 Impact factor: 1.987

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Journal: Nature Date: 2009-08-09 Impact factor: 49.962

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Journal: Aging Cell Date: 2010-10-21 Impact factor: 9.304

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Journal: Genes Dev Date: 1999-10-01 Impact factor: 11.361

7. Somatic coding mutations in human induced pluripotent stem cells.

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Journal: Nature Date: 2011-03-03 Impact factor: 49.962

8. Epigenetic predictor of age.

Authors: Sven Bocklandt; Wen Lin; Mary E Sehl; Francisco J Sánchez; Janet S Sinsheimer; Steve Horvath; Eric Vilain
Journal: PLoS One Date: 2011-06-22 Impact factor: 3.240

9. Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population.

Authors: Jordana T Bell; Pei-Chien Tsai; Tsun-Po Yang; Ruth Pidsley; James Nisbet; Daniel Glass; Massimo Mangino; Guangju Zhai; Feng Zhang; Ana Valdes; So-Youn Shin; Emma L Dempster; Robin M Murray; Elin Grundberg; Asa K Hedman; Alexandra Nica; Kerrin S Small; Emmanouil T Dermitzakis; Mark I McCarthy; Jonathan Mill; Tim D Spector; Panos Deloukas
Journal: PLoS Genet Date: 2012-04-19 Impact factor: 5.917

10. Direct cell reprogramming is a stochastic process amenable to acceleration.

Authors: Jacob Hanna; Krishanu Saha; Bernardo Pando; Jeroen van Zon; Christopher J Lengner; Menno P Creyghton; Alexander van Oudenaarden; Rudolf Jaenisch
Journal: Nature Date: 2009-11-08 Impact factor: 49.962

58 in total

Review 1. Epigenetic regulation of ageing: linking environmental inputs to genomic stability.

Authors: Bérénice A Benayoun; Elizabeth A Pollina; Anne Brunet
Journal: Nat Rev Mol Cell Biol Date: 2015-09-16 Impact factor: 94.444

2. NF-κB activation impairs somatic cell reprogramming in ageing.

Authors: Clara Soria-Valles; Fernando G Osorio; Ana Gutiérrez-Fernández; Alejandro De Los Angeles; Clara Bueno; Pablo Menéndez; José I Martín-Subero; George Q Daley; José M P Freije; Carlos López-Otín
Journal: Nat Cell Biol Date: 2015-07-27 Impact factor: 28.824

3. Simultaneous reprogramming and gene editing of human fibroblasts.

Authors: Sara E Howden; James A Thomson; Melissa H Little
Journal: Nat Protoc Date: 2018-04-05 Impact factor: 13.491

Review 4. Proceedings: consideration of genetics in the design of induced pluripotent stem cell-based models of complex disease.

Authors: Uta Grieshammer; Kelly A Shepard
Journal: Stem Cells Transl Med Date: 2014-11 Impact factor: 6.940

Review 5. The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span.

Authors: Felipe Sierra
Journal: Cold Spring Harb Perspect Med Date: 2016-04-01 Impact factor: 6.915

6. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.

Authors: Alejandro Ocampo; Pradeep Reddy; Paloma Martinez-Redondo; Aida Platero-Luengo; Fumiyuki Hatanaka; Tomoaki Hishida; Mo Li; David Lam; Masakazu Kurita; Ergin Beyret; Toshikazu Araoka; Eric Vazquez-Ferrer; David Donoso; Jose Luis Roman; Jinna Xu; Concepcion Rodriguez Esteban; Gabriel Nuñez; Estrella Nuñez Delicado; Josep M Campistol; Isabel Guillen; Pedro Guillen; Juan Carlos Izpisua Belmonte
Journal: Cell Date: 2016-12-15 Impact factor: 41.582