Literature DB >> 2314472

Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice.

T Enver1, N Raich, A J Ebens, T Papayannopoulou, F Costantini, G Stamatoyannopoulos.   

Abstract

Transgenic mice containing a human fetal (gamma-) or adult (beta-) globin gene linked to the beta-globin gene locus activation region (LAR) express the gene throughout development. By contrast, transgenic mice containing LAR linked to both a fetal and an adult globin gene display the normal developmental switch from fetal to adult gene expression. This suggests that the human fetal-to-adult globin gene switch is controlled through a mutually exclusive interaction between LAR and either the gamma- or beta-globin gene, resulting in the expression of only one gene at any given moment.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2314472     DOI： 10.1038/344309a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  128 in total

1.  The role of trans-acting factors and DNA-bending in the silencing of human beta-globin gene expression.

Authors:  L R Drew; D C Tang; P E Berg; G P Rodgers
Journal:  Nucleic Acids Res       Date:  2000-07-15       Impact factor: 16.971

2.  Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein.

Authors:  P A Ney; B P Sorrentino; C H Lowrey; A W Nienhuis
Journal:  Nucleic Acids Res       Date:  1990-10-25       Impact factor: 16.971

3.  Beta-globin locus activation regions: conservation of organization, structure, and function.

Authors:  Q L Li; B Zhou; P Powers; T Enver; G Stamatoyannopoulos
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

Review 4.  The regulatory network controlling beta-globin gene switching.

Authors:  W Shen; D P Liu; C C Liang
Journal:  Mol Biol Rep       Date:  2001       Impact factor: 2.316

Review 5.  Future prospects for treatment of hemoglobinopathies.

Authors:  J A Stamatoyannopoulos
Journal:  West J Med       Date:  1992-12

6.  Selective expression of human X chromosome-linked green opsin genes.

Authors:  J Winderickx; L Battisti; A G Motulsky; S S Deeb
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-15       Impact factor: 11.205

7.  Transcription of the hypersensitive site HS2 enhancer in erythroid cells.

Authors:  D Tuan; S Kong; K Hu
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

8.  Functional erythroid promoters created by interaction of the transcription factor GATA-1 with CACCC and AP-1/NFE-2 elements.

Authors:  M Walters; D I Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

9.  Regulated expression of the human beta globin gene in transgenic mice requires an upstream globin or nonglobin promoter.

Authors:  K P Anderson; J A Lloyd; E Ponce; S C Crable; J C Neumann; J B Lingrel
Journal:  Mol Biol Cell       Date:  1993-10       Impact factor: 4.138

10.  Human G gamma and A gamma globin gene constructs containing the 3' A gamma enhancer show persistent fetal expression in transgenic mice.

Authors:  M P Harvey; J Crosbie; R J Trent
Journal:  Transgenic Res       Date:  1993-03       Impact factor: 2.788
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.