Literature DB >> 23139856

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.

John C Morris1, Paul S Aisen, Randall J Bateman, Tammie L S Benzinger, Nigel J Cairns, Anne M Fagan, Bernardino Ghetti, Alison M Goate, David M Holtzman, William E Klunk, Eric McDade, Daniel S Marcus, Ralph N Martins, Colin L Masters, Richard Mayeux, Angela Oliver, Kimberly Quaid, John M Ringman, Martin N Rossor, Stephen Salloway, Peter R Schofield, Natalie J Selsor, Reisa A Sperling, Michael W Weiner, Chengjie Xiong, Krista L Moulder, Virginia D Buckles.   

Abstract

The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer disease (AD) centers that are conducting a multifaceted prospective biomarker study in individuals at-risk for autosomal dominant AD (ADAD). DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic ADAD mutation carriers and their non-carrier family members to determine the pathochronology of clinical, cognitive, neuroimaging, and fluid biomarkers of AD. This article describes the structure, implementation, and underlying principles of DIAN, as well as the demographic features of the initial DIAN cohort.

Entities:  

Year:  2012        PMID： 23139856      PMCID： PMC3489185          DOI： 10.4155/cli.12.93

Source DB:  PubMed          Journal:  Clin Investig (Lond)        ISSN： 2041-6792


  25 in total

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2.  A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

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Journal:  Nature       Date:  2012-08-02       Impact factor: 49.962

3.  Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults.

Authors:  Anne M Fagan; Catherine M Roe; Chengjie Xiong; Mark A Mintun; John C Morris; David M Holtzman
Journal:  Arch Neurol       Date:  2007-01-08

4.  Cerebrospinal fluid levels of β-amyloid 1-42, but not of tau, are fully changed already 5 to 10 years before the onset of Alzheimer dementia.

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Review 8.  The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

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Review 9.  The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery.

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10.  CSF tau/Abeta42 ratio for increased risk of mild cognitive impairment: a follow-up study.

Authors:  G Li; I Sokal; J F Quinn; J B Leverenz; M Brodey; G D Schellenberg; J A Kaye; M A Raskind; J Zhang; E R Peskind; T J Montine
Journal:  Neurology       Date:  2007-08-14       Impact factor: 9.910
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  104 in total

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Review 3.  Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial.

Authors:  S M Mills; J Mallmann; A M Santacruz; A Fuqua; M Carril; P S Aisen; M C Althage; S Belyew; T L Benzinger; W S Brooks; V D Buckles; N J Cairns; D Clifford; A Danek; A M Fagan; M Farlow; N Fox; B Ghetti; A M Goate; D Heinrichs; R Hornbeck; C Jack; M Jucker; W E Klunk; D S Marcus; R N Martins; C M Masters; R Mayeux; E McDade; J C Morris; A Oliver; J M Ringman; M N Rossor; S Salloway; P R Schofield; J Snider; P Snyder; R A Sperling; C Stewart; R G Thomas; C Xiong; R J Bateman
Journal:  Rev Neurol (Paris)       Date:  2013-09-06       Impact factor: 2.607

Review 4.  Progress and prospects for genetic modification of nonhuman primate models in biomedical research.

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5.  Autosomal Dominantly Inherited Alzheimer Disease: Analysis of genetic subgroups by Machine Learning.

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6.  Clinical and psychological characteristics of the initial cohort of the Dominantly Inherited Alzheimer Network (DIAN).

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Journal:  Neuropsychology       Date:  2013-11-11       Impact factor: 3.295

7.  Partial volume correction in quantitative amyloid imaging.

Authors:  Yi Su; Tyler M Blazey; Abraham Z Snyder; Marcus E Raichle; Daniel S Marcus; Beau M Ances; Randall J Bateman; Nigel J Cairns; Patricia Aldea; Lisa Cash; Jon J Christensen; Karl Friedrichsen; Russ C Hornbeck; Angela M Farrar; Christopher J Owen; Richard Mayeux; Adam M Brickman; William Klunk; Julie C Price; Paul M Thompson; Bernadino Ghetti; Andrew J Saykin; Reisa A Sperling; Keith A Johnson; Peter R Schofield; Virginia Buckles; John C Morris; Tammie L S Benzinger
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8.  Subjects harboring presenilin familial Alzheimer's disease mutations exhibit diverse white matter biochemistry alterations.

Authors:  Alex E Roher; Chera L Maarouf; Michael Malek-Ahmadi; Jeffrey Wilson; Tyler A Kokjohn; Ian D Daugs; Charisse M Whiteside; Walter M Kalback; Mimi P Macias; Sandra A Jacobson; Marwan N Sabbagh; Bernardino Ghetti; Thomas G Beach
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9.  BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease.

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Journal:  Brain       Date:  2016-08-12       Impact factor: 13.501

Review 10.  The Role of Sex and Sex Hormones in Neurodegenerative Diseases.

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Journal:  Endocr Rev       Date:  2020-04-01       Impact factor: 19.871
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