| Literature DB >> 23136829 |
Wenjun Zhang1, Zhong Liu, Sumei Li, Yongzhi Lu, Yuchan Chen, Haibo Zhang, Guangtao Zhang, Yiguang Zhu, Gaiyun Zhang, Weimin Zhang, Jinsong Liu, Changsheng Zhang.
Abstract
The strain SCSIO N160 was isolated from a South China Sea sediment sample and was characterized as a Micromonospora rosaria species on the basis of its 16S rRNA gene sequence. Three new fluostatins, I-K (1-3), were isolated from the culture of M. rosaria SCSIO N160, together with six known compounds, fluostatins C-F (4-7), rabelomycin (8), and phenanthroviridone (9). The structure of fluostatin D (5) was confirmed by an X-ray crystallographic study. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations. Compounds 8 and 9 exhibited good antimicrobial activities against Staphylococcus aureus ATCC 29213 with MIC values of 1.0 and 0.25 μg/mL, respectively. Compound 9 also exhibited significant in vitro cytotoxic activities toward SF-268 (IC50 0.09 μM) and MCF-7 (IC50 0.17 μM).Entities:
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Year: 2012 PMID： 23136829 DOI： 10.1021/np300505y
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050