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Literature DB >> 17661472

Peptide nucleic acid synthesis by novel amide formation.

Hyunil Lee¹, Jae Hoon Jeon, Jong Chan Lim, Hoon Choi, Yeohong Yoon, Sung Kee Kim.

Abstract

Synthesis of self-activated peptide nucleic acid (PNA) monomers and an efficient method for PNA synthesis using a benzothiazole-2-sulfonyl (Bts) group as an amine-protecting group as well as an acid-activating group are reported. Couplings were complete within 120 min, and the deprotection was performed in 10 min. This Bts strategy provides a high purity PNA oligomer and is appropriate for large-scale synthesis. The results of the 15-mer PNA oligomer are described.

Entities: Chemical

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Year: 2007 PMID： 17661472 DOI： 10.1021/ol071215h

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

6 in total

1. Wash-free, electrochemical platform for the quantitative, multiplexed detection of specific antibodies.

Authors: Ryan J White; Hannah M Kallewaard; Wen Hsieh; Adriana S Patterson; Jesse B Kasehagen; Kevin J Cash; Takanori Uzawa; H Tom Soh; Kevin W Plaxco
Journal: Anal Chem Date: 2012-01-03 Impact factor: 6.986

2. Peptide nucleic acid array for detection of point mutations in hepatitis B virus associated with antiviral resistance.

Authors: Hyunjung Jang; Jihyun Kim; Jae-jin Choi; Yeojin Son; Heekyung Park
Journal: J Clin Microbiol Date: 2010-06-23 Impact factor: 5.948

6. Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs.

Authors: Julien Tailhades; Hotake Takizawa; Michael J Gait; Don A Wellings; John D Wade; Yoshitsugu Aoki; Fazel Shabanpoor
Journal: Front Chem Date: 2017-10-17 Impact factor: 5.221

6 in total

Peptide nucleic acid synthesis by novel amide formation.

1. Wash-free, electrochemical platform for the quantitative, multiplexed detection of specific antibodies.

2. Peptide nucleic acid array for detection of point mutations in hepatitis B virus associated with antiviral resistance.

3. Efficient inhibition of miR-155 function in vivo by peptide nucleic acids.

4. Peptide nucleic acid-based array for detecting and genotyping human papillomaviruses.

5. PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells.

6. Solid-Phase Synthesis of Difficult Purine-Rich PNAs through Selective Hmb Incorporation: Application to the Total Synthesis of Cell Penetrating Peptide-PNAs.