| Literature DB >> 17177383 |
Takehisa Ishimaru1, Norio Shibata, Jun Nagai, Shuichi Nakamura, Takeshi Toru, Shuji Kanemasa.
Abstract
The first catalytic enantioselective hydroxylation reaction of both 3-aryl and 3-alkyl-2-oxindoles using the DBFOX-Zn(II) complex, leading to pharmaceutically important chiral 3-hydroxy-2-oxindoles was described. The structure of oxidant was found to play an important role to increase the enantioselectivity. The methodology has successfully applied to the highly enantioselective hydroxylation of beta-keto esters using the DBFOX-Ni(II) complex.Entities:
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Year: 2006 PMID： 17177383 DOI： 10.1021/ja0668825
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419