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Literature DB >> 23105386

Effect of herbal hypoglycemic agents on oxidative stress and antioxidant status in diabetic rats.

Abbas Ali Mahdi¹, Anu Chandra, Raj Kumar Singh, Sanjeev Shukla, L C Mishra, Sohail Ahmad.

Abstract

In the present study the antioxidative potential ofMomordica charantia, Azadirachta indica, Allium sativum andOcimum sanctum was assessed in streptozotocin induced diabetic rats. Lipid peroxide levels were also measured in normal, diabetic and treated animals. Malondialdehyde (MDA) levels were significantly higher and antioxidant activity was found low in diabetic groups as compared to the control groups, and significant alteration in both the MDA levels and antioxidant activity was also observed when the above herbal hypoglycemic agents were given to diabetic rats. On the basis of our results we conclude thatM. charantia, A. indica, A. sativum andO. sanctum are not only useful in controlling the lipid peroxide levels but are also helpful in further strengthening the antioxidant potential.

Entities: Chemical Disease Species

Keywords: Free radicals; antioxidants; diabetes mellitus; herbal hypoglycemic agents

Year: 2003 PMID： 23105386 PMCID： PMC3453893 DOI： 10.1007/BF02867361

Source DB: PubMed Journal: Indian J Clin Biochem ISSN： 0970-1915

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4 in total

1. Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles.

Authors: Kantha Deivi Arunachalam; Lilly Baptista Arun; Sathesh Kumar Annamalai; Aarrthy M Arunachalam
Journal: Int J Nanomedicine Date: 2014-12-16