| Literature DB >> 2255210 |
E H Karunanayake1, S Jeevathayaparan, K H Tennekoon.
Abstract
The oral hypoglycaemic activity of Momordica charantia fruit juice was investigated in rats with streptozotocin-induced diabetes. Oral administration of the juice (10 ml/kg for 30 days) did not show a significant effect, either acute or cumulative, on the ability to tolerate an external glucose load. The glycosylated haemoglobin concentrations were significantly elevated in both juice-treated and untreated diabetic rats and there was no significant difference between the two groups. Viable beta-cells capable of secreting insulin upon stimulation appear to be required for M. charantia to exert its oral hypoglycaemic activity.Entities:
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Year: 1990 PMID： 2255210 DOI： 10.1016/0378-8741(90)90008-h
Source DB: PubMed Journal: J Ethnopharmacol ISSN： 0378-8741 Impact factor: 4.360