PURPOSE: We performed a prospective randomized study to assess the effectiveness of short-term intravenous antimicrobial prophylaxis in combination with preoperative oral antibiotics on a surgical site and methicillin-resistant Staphylococcus aureus (MRSA) infection in elective colon cancer surgery. METHODS: The patients were administered preoperative oral antibiotics, kanamycin and erythromycin, after mechanical cleansing, which began within 24 h of elective surgery for colon cancer. The patients were randomly assigned to receive the intravenous administration of cefmetazol or cefotiam on the day of surgery (group 1) or for 3 days (group 2). A total of 275 patients (136 for group 1 and 139 for group 2) were eligible for the study. RESULTS: The incidence of a surgical site infection was 5.1% in group 1 and 6.5% in group 2 (P = 0.80). The incidence of MRSA infection was 2.2% in group 1 and 2.9% in group 2 (P > 0.99). A multivariate logistic regression analysis showed that the American Society of Anesthesiologists physical status score and the duration of surgery were independent significant factors affecting the surgical site infection and MRSA infection. CONCLUSION: These findings suggest that short-term intravenous antimicrobial prophylaxis in combination with preoperative oral antibiotics may be successfully applied to colon cancer surgery that is generally performed in Japan.
RCT Entities:
PURPOSE: We performed a prospective randomized study to assess the effectiveness of short-term intravenous antimicrobial prophylaxis in combination with preoperative oral antibiotics on a surgical site and methicillin-resistant Staphylococcus aureus (MRSA) infection in elective colon cancer surgery. METHODS: The patients were administered preoperative oral antibiotics, kanamycin and erythromycin, after mechanical cleansing, which began within 24 h of elective surgery for colon cancer. The patients were randomly assigned to receive the intravenous administration of cefmetazol or cefotiam on the day of surgery (group 1) or for 3 days (group 2). A total of 275 patients (136 for group 1 and 139 for group 2) were eligible for the study. RESULTS: The incidence of a surgical site infection was 5.1% in group 1 and 6.5% in group 2 (P = 0.80). The incidence of MRSA infection was 2.2% in group 1 and 2.9% in group 2 (P > 0.99). A multivariate logistic regression analysis showed that the American Society of Anesthesiologists physical status score and the duration of surgery were independent significant factors affecting the surgical site infection and MRSA infection. CONCLUSION: These findings suggest that short-term intravenous antimicrobial prophylaxis in combination with preoperative oral antibiotics may be successfully applied to colon cancer surgery that is generally performed in Japan.
Authors: Y Takesue; T Yokoyama; S Akagi; H Ohge; Y Murakami; Y Sakashita; K Miyamoto; K Uemura; H Itaha; Y Matsuura Journal: Surg Today Date: 2000 Impact factor: 2.549
Authors: Mehrdad Nikfarjam; Laurence Weinberg; Michael A Fink; Vijayaragavan Muralidharan; Graham Starkey; Robert Jones; Kevin Staveley-O'Carroll; Christopher Christophi Journal: World J Surg Date: 2014-02 Impact factor: 3.352
Authors: Adam Bobkiewicz; Adam Studniarek; Lukasz Krokowicz; Krzysztof Szmyt; Maciej Borejsza-Wysocki; Jacek Szmeja; Ryszard Marciniak; Michal Drews; Tomasz Banasiewicz Journal: Int J Colorectal Dis Date: 2016-09-30 Impact factor: 2.571