PURPOSE: Soft tissue sarcomas (STS) are uncommon tumours with varying histological subtypes. There is a paucity of available data concerning the quality-of-life (QoL) impact of STS which could be used to support economic evaluation of future treatments. This study aimed to elicit societal utility values for health states that depict the impact of STS and its treatment. METHODS: Following the development of eight health state vignettes, a sample of 100 members of the UK general public participated in a valuation exercise to elicit utility values using the time trade-off procedure. RESULTS: The treatment response state was valued as the least burdensome by participants followed by the prospect of stable disease (mean utility value: 0.736 SD 0.21). Serious adverse events were associated with a range of disutilities from -0.236 for grade III/IV pain to -0.357 for grade III/IV nausea/vomiting. Progressive disease was deemed the least desirable outcome and was associated with a substantial decline in utility (-0.473). CONCLUSIONS: Findings suggest advanced STS are associated with significant burden for individuals. Treatment-related adverse events were seen as debilitating, however, progression represents an enormous challenge to QoL. This illustrates the significant value to individuals of extending the progression free survival period.
PURPOSE: Soft tissue sarcomas (STS) are uncommon tumours with varying histological subtypes. There is a paucity of available data concerning the quality-of-life (QoL) impact of STS which could be used to support economic evaluation of future treatments. This study aimed to elicit societal utility values for health states that depict the impact of STS and its treatment. METHODS: Following the development of eight health state vignettes, a sample of 100 members of the UK general public participated in a valuation exercise to elicit utility values using the time trade-off procedure. RESULTS: The treatment response state was valued as the least burdensome by participants followed by the prospect of stable disease (mean utility value: 0.736 SD 0.21). Serious adverse events were associated with a range of disutilities from -0.236 for grade III/IV pain to -0.357 for grade III/IV nausea/vomiting. Progressive disease was deemed the least desirable outcome and was associated with a substantial decline in utility (-0.473). CONCLUSIONS: Findings suggest advanced STS are associated with significant burden for individuals. Treatment-related adverse events were seen as debilitating, however, progression represents an enormous challenge to QoL. This illustrates the significant value to individuals of extending the progression free survival period.
Authors: Paul Swinburn; Andrew Lloyd; Paul Nathan; Toni K Choueiri; David Cella; Maureen P Neary Journal: Curr Med Res Opin Date: 2010-05 Impact factor: 2.580
Authors: Vincent Berry; Laurent Basson; Emilie Bogart; Olivier Mir; Jean-Yves Blay; Antoine Italiano; François Bertucci; Christine Chevreau; Stéphanie Clisant-Delaine; Bernadette Liegl-Antzager; Emmanuelle Tresch-Bruneel; Jennifer Wallet; Sophie Taieb; Emilie Decoupigny; Axel Le Cesne; Thomas Brodowicz; Nicolas Penel Journal: Cancer Date: 2017-03-10 Impact factor: 6.860
Authors: Jonathan F Dalton; Ryan Furdock; Landon Cluts; Bharadwaj Jilakara; Douglas Mcdonald; Ryan Calfee; Cara Cipriano Journal: Cureus Date: 2022-05-31
Authors: Mrinal Gounder; Albiruni R Abdul Razak; Adrienne M Gilligan; Hoyee Leong; Xiwen Ma; Neeta Somaiah; Sant P Chawla; Javier Martin-Broto; Giovanni Grignani; Scott M Schuetze; Bruno Vincenzi; Andrew J Wagner; Bartosz Chmielowski; Robin L Jones; Jatin Shah; Sharon Shacham; Michael Kauffman; Richard F Riedel; Steven Attia Journal: Future Oncol Date: 2021-04-15 Impact factor: 3.674