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Literature DB >> 23095384

Non-Mendelian etiologic factors in neuropsychiatric illness: pleiotropy, epigenetics, and convergence.

Abstract

The target article by Charney on behavior genetics/genomics discusses how numerous molecular factors can inform heritability estimations and genetic association studies. These factors find application in the search for genes for behavioral phenotypes, including neuropsychiatric disorders. We elaborate upon how single causal factors can generate multiple phenotypes, and discuss how multiple causal factors may converge on common neurodevelopmental mechanisms.

Entities: Disease Gene Species

Mesh：

Year: 2012 PMID： 23095384 PMCID： PMC3563321 DOI： 10.1017/S0140525X12001392

Source DB: PubMed Journal: Behav Brain Sci ISSN： 0140-525X Impact factor: 12.579

21 in total

Review 1. The genetics of health.

Authors: Joseph H Nadeau; Eric J Topol
Journal: Nat Genet Date: 2006-10 Impact factor: 38.330

2. Heterogeneity and hypothesis testing in neuropsychiatric illness.

Authors: Curtis K Deutsch; Wesley W Ludwig; William J McIlvane
Journal: Behav Brain Sci Date: 2008-06 Impact factor: 12.579

3. Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD.

Authors: Heike Weber; Sarah Kittel-Schneider; Alexandra Gessner; Katharina Domschke; Maria Neuner; Christian P Jacob; Henriette N Buttenschon; Andrea Boreatti-Hümmer; Julia Volkert; Sabine Herterich; Bernhard T Baune; Silke Gross-Lesch; Juliane Kopf; Susanne Kreiker; Thuy Trang Nguyen; Lena Weissflog; Volker Arolt; Ole Mors; Jürgen Deckert; Klaus-Peter Lesch; Andreas Reif
Journal: Neuropsychopharmacology Date: 2011-06-08 Impact factor: 7.853

4. De novo mutations revealed by whole-exome sequencing are strongly associated with autism.

Authors: Stephan J Sanders; Michael T Murtha; Abha R Gupta; John D Murdoch; Melanie J Raubeson; A Jeremy Willsey; A Gulhan Ercan-Sencicek; Nicholas M DiLullo; Neelroop N Parikshak; Jason L Stein; Michael F Walker; Gordon T Ober; Nicole A Teran; Youeun Song; Paul El-Fishawy; Ryan C Murtha; Murim Choi; John D Overton; Robert D Bjornson; Nicholas J Carriero; Kyle A Meyer; Kaya Bilguvar; Shrikant M Mane; Nenad Sestan; Richard P Lifton; Murat Günel; Kathryn Roeder; Daniel H Geschwind; Bernie Devlin; Matthew W State
Journal: Nature Date: 2012-04-04 Impact factor: 49.962

Review 5. Genomewide association studies: history, rationale, and prospects for psychiatric disorders.

Authors: Sven Cichon; Nick Craddock; Mark Daly; Stephen V Faraone; Pablo V Gejman; John Kelsoe; Thomas Lehner; Douglas F Levinson; Audra Moran; Pamela Sklar; Patrick F Sullivan
Journal: Am J Psychiatry Date: 2009-04-01 Impact factor: 18.112

6. Extending the phenotype of recurrent rearrangements of 16p11.2: deletions in mentally retarded patients without autism and in normal individuals.

Authors: E K Bijlsma; A C J Gijsbers; J H M Schuurs-Hoeijmakers; A van Haeringen; D E Fransen van de Putte; B-M Anderlid; J Lundin; P Lapunzina; L A Pérez Jurado; B Delle Chiaie; B Loeys; B Menten; A Oostra; H Verhelst; D J Amor; D L Bruno; A J van Essen; R Hordijk; B Sikkema-Raddatz; K T Verbruggen; M C J Jongmans; R Pfundt; H M Reeser; M H Breuning; C A L Ruivenkamp
Journal: Eur J Med Genet Date: 2009-03-21 Impact factor: 2.708

7. Transcriptomic analysis of autistic brain reveals convergent molecular pathology.

Authors: Irina Voineagu; Xinchen Wang; Patrick Johnston; Jennifer K Lowe; Yuan Tian; Steve Horvath; Jonathan Mill; Rita M Cantor; Benjamin J Blencowe; Daniel H Geschwind
Journal: Nature Date: 2011-05-25 Impact factor: 49.962

8. Patterns and rates of exonic de novo mutations in autism spectrum disorders.

Authors: Benjamin M Neale; Yan Kou; Li Liu; Avi Ma'ayan; Kaitlin E Samocha; Aniko Sabo; Chiao-Feng Lin; Christine Stevens; Li-San Wang; Vladimir Makarov; Paz Polak; Seungtai Yoon; Jared Maguire; Emily L Crawford; Nicholas G Campbell; Evan T Geller; Otto Valladares; Chad Schafer; Han Liu; Tuo Zhao; Guiqing Cai; Jayon Lihm; Ruth Dannenfelser; Omar Jabado; Zuleyma Peralta; Uma Nagaswamy; Donna Muzny; Jeffrey G Reid; Irene Newsham; Yuanqing Wu; Lora Lewis; Yi Han; Benjamin F Voight; Elaine Lim; Elizabeth Rossin; Andrew Kirby; Jason Flannick; Menachem Fromer; Khalid Shakir; Tim Fennell; Kiran Garimella; Eric Banks; Ryan Poplin; Stacey Gabriel; Mark DePristo; Jack R Wimbish; Braden E Boone; Shawn E Levy; Catalina Betancur; Shamil Sunyaev; Eric Boerwinkle; Joseph D Buxbaum; Edwin H Cook; Bernie Devlin; Richard A Gibbs; Kathryn Roeder; Gerard D Schellenberg; James S Sutcliffe; Mark J Daly
Journal: Nature Date: 2012-04-04 Impact factor: 49.962

9. Microduplications of 16p11.2 are associated with schizophrenia.

Authors: Shane E McCarthy; Vladimir Makarov; George Kirov; Anjene M Addington; Jon McClellan; Seungtai Yoon; Diana O Perkins; Diane E Dickel; Mary Kusenda; Olga Krastoshevsky; Verena Krause; Ravinesh A Kumar; Detelina Grozeva; Dheeraj Malhotra; Tom Walsh; Elaine H Zackai; Paige Kaplan; Jaya Ganesh; Ian D Krantz; Nancy B Spinner; Patricia Roccanova; Abhishek Bhandari; Kevin Pavon; B Lakshmi; Anthony Leotta; Jude Kendall; Yoon-Ha Lee; Vladimir Vacic; Sydney Gary; Lilia M Iakoucheva; Timothy J Crow; Susan L Christian; Jeffrey A Lieberman; T Scott Stroup; Terho Lehtimäki; Kaija Puura; Chad Haldeman-Englert; Justin Pearl; Meredith Goodell; Virginia L Willour; Pamela Derosse; Jo Steele; Layla Kassem; Jessica Wolff; Nisha Chitkara; Francis J McMahon; Anil K Malhotra; James B Potash; Thomas G Schulze; Markus M Nöthen; Sven Cichon; Marcella Rietschel; Ellen Leibenluft; Vlad Kustanovich; Clara M Lajonchere; James S Sutcliffe; David Skuse; Michael Gill; Louise Gallagher; Nancy R Mendell; Nick Craddock; Michael J Owen; Michael C O'Donovan; Tamim H Shaikh; Ezra Susser; Lynn E Delisi; Patrick F Sullivan; Curtis K Deutsch; Judith Rapoport; Deborah L Levy; Mary-Claire King; Jonathan Sebat
Journal: Nat Genet Date: 2009-10-25 Impact factor: 38.330

10. Exome sequencing in sporadic autism spectrum disorders identifies severe de novo mutations.

Authors: Brian J O'Roak; Pelagia Deriziotis; Choli Lee; Laura Vives; Jerrod J Schwartz; Santhosh Girirajan; Emre Karakoc; Alexandra P Mackenzie; Sarah B Ng; Carl Baker; Mark J Rieder; Deborah A Nickerson; Raphael Bernier; Simon E Fisher; Jay Shendure; Evan E Eichler
Journal: Nat Genet Date: 2011-05-15 Impact factor: 38.330

3 in total