Literature DB >> 24013907

Heterogeneity and hypothesis testing in neuropsychiatric illness.

Curtis K Deutsch1, Wesley W Ludwig, William J McIlvane.   

Abstract

The confounding effects of heterogeneity in biological psychiatry and psychiatric genetics have been widely discussed in the literature. We suggest an approach in which heterogeneity may be put to use in hypothesis testing and may find application in evaluation of the Crespi and Badcock (C&B) imprinting hypothesis. Here we consider three potential sources of etiologic subtypes for analysis.

Entities:  

Year:  2008        PMID： 24013907      PMCID： PMC3763735          DOI： 10.1017/S0140525X08004275

Source DB:  PubMed          Journal:  Behav Brain Sci        ISSN： 0140-525X            Impact factor:   12.579


  26 in total

Review 1.  Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework.

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2.  Autism spectrum disorders and symptoms in children with molecularly confirmed 22q11.2 deletion syndrome.

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Review 3.  The search for autism disease genes.

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5.  Large genomic duplicons map to sites of instability in the Prader-Willi/Angelman syndrome chromosome region (15q11-q13).

Authors:  S L Christian; J A Fantes; S K Mewborn; B Huang; D H Ledbetter
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6.  Quantifying the phenotype in autism spectrum disorders.

Authors:  C Lord; B L Leventhal; E H Cook
Journal:  Am J Med Genet       Date:  2001-01-08

7.  Autism in Angelman syndrome: implications for autism research.

Authors:  S U Peters; A L Beaudet; N Madduri; C A Bacino
Journal:  Clin Genet       Date:  2004-12       Impact factor: 4.438

8.  A girl with neurofibromatosis type 1, atypical autism and mosaic ring chromosome 17.

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Journal:  Am J Med Genet A       Date:  2007-01-01       Impact factor: 2.802

9.  Strong association of de novo copy number mutations with autism.

Authors:  Jonathan Sebat; B Lakshmi; Dheeraj Malhotra; Jennifer Troge; Christa Lese-Martin; Tom Walsh; Boris Yamrom; Seungtai Yoon; Alex Krasnitz; Jude Kendall; Anthony Leotta; Deepa Pai; Ray Zhang; Yoon-Ha Lee; James Hicks; Sarah J Spence; Annette T Lee; Kaija Puura; Terho Lehtimäki; David Ledbetter; Peter K Gregersen; Joel Bregman; James S Sutcliffe; Vaidehi Jobanputra; Wendy Chung; Dorothy Warburton; Mary-Claire King; David Skuse; Daniel H Geschwind; T Conrad Gilliam; Kenny Ye; Michael Wigler
Journal:  Science       Date:  2007-03-15       Impact factor: 47.728

Review 10.  Autism and tuberous sclerosis.

Authors:  S L Smalley
Journal:  J Autism Dev Disord       Date:  1998-10
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  2 in total

Review 1.  Attention deficits, Attention-Deficit Hyperactivity Disorder, and intellectual disabilities.

Authors:  Curtis K Deutsch; William V Dube; William J McIlvane
Journal:  Dev Disabil Res Rev       Date:  2008

2.  Non-Mendelian etiologic factors in neuropsychiatric illness: pleiotropy, epigenetics, and convergence.

Authors:  Curtis K Deutsch; William J McIlvane
Journal:  Behav Brain Sci       Date:  2012-10       Impact factor: 12.579
  2 in total

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