Literature DB >> 17006459

The genetics of health.

Joseph H Nadeau1, Eric J Topol.   

Abstract

Recent experience with several high-profile drugs demonstrates the great challenges in developing effective and safe therapeutics. A complementary approach to the popular paradigm of disease genetics is based on inherited factors that reduce the incidence and severity of disease among individuals who are genetically predisposed to disease. We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health.

Mesh：

Year:  2006        PMID： 17006459     DOI： 10.1038/ng1006-1095

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  22 in total

Review 1.  Functional interactions among morphologic and tissue quality traits define bone quality.

Authors:  Karl J Jepsen
Journal:  Clin Orthop Relat Res       Date:  2011-08       Impact factor: 4.176

Review 2.  Protective alleles and modifier variants in human health and disease.

Authors:  Andrew R Harper; Shalini Nayee; Eric J Topol
Journal:  Nat Rev Genet       Date:  2015-10-27       Impact factor: 53.242

3.  A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.

Authors:  Richard H Duerr; Kent D Taylor; Steven R Brant; John D Rioux; Mark S Silverberg; Mark J Daly; A Hillary Steinhart; Clara Abraham; Miguel Regueiro; Anne Griffiths; Themistocles Dassopoulos; Alain Bitton; Huiying Yang; Stephan Targan; Lisa Wu Datta; Emily O Kistner; L Philip Schumm; Annette T Lee; Peter K Gregersen; M Michael Barmada; Jerome I Rotter; Dan L Nicolae; Judy H Cho
Journal:  Science       Date:  2006-10-26       Impact factor: 47.728

4.  A new era in psychiatric genetics?

Authors:  Thomas R Insel; Thomas Lehner
Journal:  Biol Psychiatry       Date:  2007-05-01       Impact factor: 13.382

5.  Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.

Authors:  Haifeng Shao; Lindsay C Burrage; David S Sinasac; Annie E Hill; Sheila R Ernest; William O'Brien; Hayden-William Courtland; Karl J Jepsen; Andrew Kirby; E J Kulbokas; Mark J Daly; Karl W Broman; Eric S Lander; Joseph H Nadeau
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-09       Impact factor: 11.205

6.  Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks.

Authors:  Atila van Nas; Debraj Guhathakurta; Susanna S Wang; Nadir Yehya; Steve Horvath; Bin Zhang; Leslie Ingram-Drake; Gautam Chaudhuri; Eric E Schadt; Thomas A Drake; Arthur P Arnold; Aldons J Lusis
Journal:  Endocrinology       Date:  2008-10-30       Impact factor: 4.736

Review 7.  From Peas to Disease: Modifier Genes, Network Resilience, and the Genetics of Health.

Authors:  Jesse D Riordan; Joseph H Nadeau
Journal:  Am J Hum Genet       Date:  2017-08-03       Impact factor: 11.025

8.  Modifier genes and non-genetic factors reshape anatomical deficits in Zfp423-deficient mice.

Authors:  Wendy A Alcaraz; Edward Chen; Phoebe Valdes; Eunnie Kim; Yuan Hung Lo; Jennifer Vo; Bruce A Hamilton
Journal:  Hum Mol Genet       Date:  2011-07-05       Impact factor: 6.150

9.  Genome-wide search for genes that modulate inflammatory arthritis caused by Ali18 mutation in mice.

Authors:  Koichiro Abe; Matthias Klaften; Akira Narita; Tetsuaki Kimura; Kenji Imai; Minoru Kimura; Isabel Rubio-Aliaga; Sibylle Wagner; Thilo Jakob; Martin Hrabé de Angelis
Journal:  Mamm Genome       Date:  2009-02-24       Impact factor: 2.957

10.  Non-Mendelian etiologic factors in neuropsychiatric illness: pleiotropy, epigenetics, and convergence.

Authors:  Curtis K Deutsch; William J McIlvane
Journal:  Behav Brain Sci       Date:  2012-10       Impact factor: 12.579
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