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Literature DB >> 23093316

Epigenetic chemical probes.

Abstract

Epigenetic control of gene expression occurs at two distinctlevels: DNA methylation and histone modification. Over thepast 10 years, the discovery of epigenetic targets has acceleratedto the point where more than 400 domains have beenidentified that are involved in either DNA methylation, themodification of histones (and some nonhistones), or translationof these modifications into changes in gene expression

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Year: 2012 PMID： 23093316 DOI： 10.1038/clpt.2012.154

Source DB: PubMed Journal: Clin Pharmacol Ther ISSN： 0009-9236 Impact factor: 6.875

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Cited

12 in total

Review 1. Chromatin dynamics underlying latent responses to xenobiotics.

Authors: Jonathan Moggs; Rémi Terranova
Journal: Toxicol Res (Camb) Date: 2018-02-28 Impact factor: 3.524

2. Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.

Authors: Natalie H Theodoulou; Paul Bamborough; Andrew J Bannister; Isabelle Becher; Rino A Bit; Ka Hing Che; Chun-wa Chung; Antje Dittmann; Gerard Drewes; David H Drewry; Laurie Gordon; Paola Grandi; Melanie Leveridge; Matthew Lindon; Anne-Marie Michon; Judit Molnar; Samuel C Robson; Nicholas C O Tomkinson; Tony Kouzarides; Rab K Prinjha; Philip G Humphreys
Journal: J Med Chem Date: 2015-04-30 Impact factor: 7.446

3. Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain.

Authors: Young Jun Seo; Lisa Muench; Alicia Reid; Jinzhu Chen; Yeona Kang; Jacob M Hooker; Nora D Volkow; Joanna S Fowler; Sung Won Kim
Journal: Bioorg Med Chem Lett Date: 2013-10-30 Impact factor: 2.823

4. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.

Authors: Feng Liu; Fengling Li; Anqi Ma; Elena Dobrovetsky; Aiping Dong; Cen Gao; Ilia Korboukh; Jing Liu; David Smil; Peter J Brown; Stephen V Frye; Cheryl H Arrowsmith; Matthieu Schapira; Masoud Vedadi; Jian Jin
Journal: J Med Chem Date: 2013-02-27 Impact factor: 7.446

5. Frapid: achieving full automation of FRAP for chemical probe validation.

Authors: Clarence Yapp; Catherine Rogers; Pavel Savitsky; Martin Philpott; Susanne Müller
Journal: Biomed Opt Express Date: 2016-01-11 Impact factor: 3.732

Review 6. Histone Modifications and Cancer.

Authors: James E Audia; Robert M Campbell
Journal: Cold Spring Harb Perspect Biol Date: 2016-04-01 Impact factor: 10.005

Epigenetic chemical probes.

Review 1. Chromatin dynamics underlying latent responses to xenobiotics.

2. Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition.

3. Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain.

4. Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.

5. Frapid: achieving full automation of FRAP for chemical probe validation.

Review 6. Histone Modifications and Cancer.

Review 7. Targeting protein-protein interactions as an anticancer strategy.

Review 8. Open access chemical probes for epigenetic targets.

Review 9. Chemical probes targeting epigenetic proteins: Applications beyond oncology.

10. Identification of the Prognostic Signatures of Glioma With Different PTEN Status.