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Literature DB >> 27037415

Histone Modifications and Cancer.

Abstract

Histone posttranslational modifications represent a versatile set of epigenetic marks involved not only in dynamic cellular processes, such as transcription and DNA repair, but also in the stable maintenance of repressive chromatin. In this article, we review many of the key and newly identified histone modifications known to be deregulated in cancer and how this impacts function. The latter part of the article addresses the challenges and current status of the epigenetic drug development process as it applies to cancer therapeutics.

Entities: Disease

Mesh：

Substances：
Histones

Year: 2016 PMID： 27037415 PMCID： PMC4817802 DOI： 10.1101/cshperspect.a019521

Source DB: PubMed Journal: Cold Spring Harb Perspect Biol ISSN： 1943-0264 Impact factor: 10.005

230 in total

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Review 9. Epigenetic Determinants of Cancer.

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