BACKGROUND: Legumes, including beans, chickpeas, and lentils, are among the lowest glycemic index (GI) foods and have been recommended in national diabetes mellitus (DM) guidelines. Yet, to our knowledge, they have never been used specifically to lower the GI of the diet. We have therefore undertaken a study of low-GI foods in type 2 DM with a focus on legumes in the intervention. METHODS: A total of 121 participants with type 2 DM were randomized to either a low-GI legume diet that encouraged participants to increase legume intake by at least 1 cup per day, or to increase insoluble fiber by consumption of whole wheat products, for 3 months. The primary outcome was change in hemoglobinA1c (HbA1c) values with calculated coronary heart disease (CHD) risk score as a secondary outcome. RESULTS: The low-GI legume diet reduced HbA1c values by -0.5% (95% CI, -0.6% to -0.4%) and the high wheat fiber diet reduced HbA1c values by -0.3% (95% CI, -0.4% to -0.2%). The relative reduction in HbA1c values after the low-GI legume diet was greater than after the high wheat fiber diet by -0.2% (95% CI, -0.3% to -0.1%; P < .001). The respective CHD risk reduction on the low-GI legume diet was -0.8% (95% CI, -1.4% to -0.3%; P = .003), largely owing to a greater relative reduction in systolic blood pressure on the low-GI legume diet compared with the high wheat fiber diet (-4.5 mm Hg; 95% CI, -7.0 to -2.1 mm Hg; P < .001). CONCLUSION: Incorporation of legumes as part of a low-GI diet improved both glycemic control and reduced calculated CHD risk score in type 2 DM.
RCT Entities:
BACKGROUND: Legumes, including beans, chickpeas, and lentils, are among the lowest glycemic index (GI) foods and have been recommended in national diabetes mellitus (DM) guidelines. Yet, to our knowledge, they have never been used specifically to lower the GI of the diet. We have therefore undertaken a study of low-GI foods in type 2 DM with a focus on legumes in the intervention. METHODS: A total of 121 participants with type 2 DM were randomized to either a low-GI legume diet that encouraged participants to increase legume intake by at least 1 cup per day, or to increase insoluble fiber by consumption of whole wheat products, for 3 months. The primary outcome was change in hemoglobin A1c (HbA1c) values with calculated coronary heart disease (CHD) risk score as a secondary outcome. RESULTS: The low-GI legume diet reduced HbA1c values by -0.5% (95% CI, -0.6% to -0.4%) and the high wheatfiber diet reduced HbA1c values by -0.3% (95% CI, -0.4% to -0.2%). The relative reduction in HbA1c values after the low-GI legume diet was greater than after the high wheatfiber diet by -0.2% (95% CI, -0.3% to -0.1%; P < .001). The respective CHD risk reduction on the low-GI legume diet was -0.8% (95% CI, -1.4% to -0.3%; P = .003), largely owing to a greater relative reduction in systolic blood pressure on the low-GI legume diet compared with the high wheatfiber diet (-4.5 mm Hg; 95% CI, -7.0 to -2.1 mm Hg; P < .001). CONCLUSION: Incorporation of legumes as part of a low-GI diet improved both glycemic control and reduced calculated CHD risk score in type 2 DM.
Authors: Vanessa Ha; John L Sievenpiper; Russell J de Souza; Viranda H Jayalath; Arash Mirrahimi; Arnav Agarwal; Laura Chiavaroli; Sonia Blanco Mejia; Frank M Sacks; Marco Di Buono; Adam M Bernstein; Lawrence A Leiter; Penny M Kris-Etherton; Vladimir Vuksan; Richard P Bazinet; Robert G Josse; Joseph Beyene; Cyril W C Kendall; David J A Jenkins Journal: CMAJ Date: 2014-04-07 Impact factor: 8.262
Authors: Sonia S Anand; Corinna Hawkes; Russell J de Souza; Andrew Mente; Mahshid Dehghan; Rachel Nugent; Michael A Zulyniak; Tony Weis; Adam M Bernstein; Ronald M Krauss; Daan Kromhout; David J A Jenkins; Vasanti Malik; Miguel A Martinez-Gonzalez; Dariush Mozaffarian; Salim Yusuf; Walter C Willett; Barry M Popkin Journal: J Am Coll Cardiol Date: 2015-10-06 Impact factor: 24.094
Authors: Daniel J Cox; Ann Gill Taylor; Elizabeth S Dunning; Mary C Winston; Ingrid L Luk Van; Anthony McCall; Harsimran Singh; William S Yancy Journal: Curr Diab Rep Date: 2013-12 Impact factor: 4.810