F Nouri1,2, N Sarrafzadegan1, N Mohammadifard3, M Sadeghi4, M Mansourian2. 1. Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. 3. Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. 4. Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Abstract
BACKGROUND/ OBJECTIVES: The purpose of this study was to explore the association of legume intake (beans, chickpeas, lentils and so on), as part of a low-glycemic index diet, with the risk of cardiovascular events in the Iranian middle- and old-aged people. SUBJECTS/ METHODS: A total of 6504 subjects living in the three counties of Iran participated in the Isfahan Cohort Study. Totally, 6323 were free of cardiovascular disease (CVD) at their baseline examination. Of the 6323 individuals, 5398 participants remained in the study for 7 years of follow-up. They have been contacted every 2 years for possible occurrence of CVD events including fatal and non-fatal myocardial infarction, unstable angina, fatal and non-fatal stroke, and sudden cardiac death. The frequency of legume intake was estimated using a food frequency questionnaire. Cox proportional hazards models with shared gamma frailty terms were used to model time to event outcomes. RESULTS: After a median follow-up of 6.8 years, 427 cardiovascular events occurred. The intake of legumes in different tertiles of consuming measure was associated with 34% lower risk of CVD in old-aged people, after controlling for the other probable confounders (hazard ratio and 95% CI: 0.66 (0.45, 0.98), P-value=0.039). However, there was no significant association between the frequency of consuming legumes and CVD events in the middle-aged people. CONCLUSIONS: The present study indicated a strong inverse relationship between legume intake and the risk of cardiovascular events in old-aged Iranian people.
BACKGROUND/ OBJECTIVES: The purpose of this study was to explore the association of legume intake (beans, chickpeas, lentils and so on), as part of a low-glycemic index diet, with the risk of cardiovascular events in the Iranian middle- and old-aged people. SUBJECTS/ METHODS: A total of 6504 subjects living in the three counties of Iran participated in the Isfahan Cohort Study. Totally, 6323 were free of cardiovascular disease (CVD) at their baseline examination. Of the 6323 individuals, 5398 participants remained in the study for 7 years of follow-up. They have been contacted every 2 years for possible occurrence of CVD events including fatal and non-fatal myocardial infarction, unstable angina, fatal and non-fatal stroke, and sudden cardiac death. The frequency of legume intake was estimated using a food frequency questionnaire. Cox proportional hazards models with shared gamma frailty terms were used to model time to event outcomes. RESULTS: After a median follow-up of 6.8 years, 427 cardiovascular events occurred. The intake of legumes in different tertiles of consuming measure was associated with 34% lower risk of CVD in old-aged people, after controlling for the other probable confounders (hazard ratio and 95% CI: 0.66 (0.45, 0.98), P-value=0.039). However, there was no significant association between the frequency of consuming legumes and CVD events in the middle-aged people. CONCLUSIONS: The present study indicated a strong inverse relationship between legume intake and the risk of cardiovascular events in old-aged Iranian people.
Authors: Simin Liu; Julie E Buring; Howard D Sesso; Eric B Rimm; Walter C Willett; JoAnn E Manson Journal: J Am Coll Cardiol Date: 2002-01-02 Impact factor: 24.094
Authors: K Ogawa; Y Tsubono; Y Nishino; Y Watanabe; T Ohkubo; T Watanabe; H Nakatsuka; N Takahashi; M Kawamura; I Tsuji; S Hisamichi Journal: Eur J Clin Nutr Date: 1999-10 Impact factor: 4.016
Authors: Stuart J Moat; Derek Lang; Ian F W McDowell; Zoe L Clarke; Anil K Madhavan; Malcolm J Lewis; Jonathan Goodfellow Journal: J Nutr Biochem Date: 2004-02 Impact factor: 6.048
Authors: Laura Chiavaroli; Arash Mirrahimi; Christopher Ireland; Sandra Mitchell; Sandhya Sahye-Pudaruth; Judy Coveney; Omodele Olowoyeye; Darshna Patel; Russell J de Souza; Livia S A Augustin; Balachandran Bashyam; Sathish Chandra Pichika; Sonia Blanco Mejia; Stephanie K Nishi; Lawrence A Leiter; Robert G Josse; Gail E McKeown-Eyssen; Alan R Moody; Cyril W C Kendall; John L Sievenpiper; David J A Jenkins Journal: BMJ Open Date: 2017-03-22 Impact factor: 2.692
Authors: Effie Viguiliouk; Andrea J Glenn; Stephanie K Nishi; Laura Chiavaroli; Maxine Seider; Tauseef Khan; Marialaura Bonaccio; Licia Iacoviello; Sonia Blanco Mejia; David J A Jenkins; Cyril W C Kendall; Hana Kahleová; Dario Rahelić; Jordi Salas-Salvadó; John L Sievenpiper Journal: Adv Nutr Date: 2019-11-01 Impact factor: 8.701
Authors: Lauren C Blekkenhorst; Marc Sim; Catherine P Bondonno; Nicola P Bondonno; Natalie C Ward; Richard L Prince; Amanda Devine; Joshua R Lewis; Jonathan M Hodgson Journal: Nutrients Date: 2018-05-11 Impact factor: 5.717
Authors: Javad Sharifi-Rad; Célia F Rodrigues; Farukh Sharopov; Anca Oana Docea; Aslı Can Karaca; Mehdi Sharifi-Rad; Derya Kahveci Karıncaoglu; Gözde Gülseren; Ezgi Şenol; Evren Demircan; Yasaman Taheri; Hafiz Ansar Rasul Suleria; Beraat Özçelik; Kadriye Nur Kasapoğlu; Mine Gültekin-Özgüven; Ceren Daşkaya-Dikmen; William C Cho; Natália Martins; Daniela Calina Journal: Int J Environ Res Public Health Date: 2020-03-30 Impact factor: 3.390